Lysosomal-Associated Membrane Protein 2 (LAMP2) antibody (FITC)

Details for Product No. ABIN371602
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Antigen
Synonyms cd107b, lamp-2, lampb, LAMP2, lamp2, DKFZp459J126, LAMP-2, LGP-B, CD107b, Lamp-2, Lamp-2a, Lamp-2b, Lamp-2c, Mac3, LAMPB, LGP110
Reactivity
Human
(126), (118), (24), (21), (13), (13), (7), (2)
Host
Mouse
(90), (86), (53), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
FITC
(31), (22), (11), (11), (5), (5), (4), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Flow Cytometry (FACS)
(103), (99), (60), (54), (48), (42), (30), (30), (28), (10), (2), (2)
Pubmed 5 references available
Quantity 100 tests
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Catalog No. ABIN371602
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Clone H4B4
Isotype IgG1
Characteristics Synonyms: LAMP-2, LAMP-2C, LAMPB, Lysosome-associated membrane glycoprotein 2
Alternative Name CD107b / LAMP2
Background CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavilyglycosylated, type I transmembrane protein that constitutes the major sialoglycoproteinson lysosomal membranes. It is a ligand for galaptin, an S-type lectin present inextracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains,and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed by granulocytes, T cells, macrophages, dendritic cells, activatedplatelets tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is alsoa widely expressed intracellular antigen. LAMP-2 may function in protecting the innersurface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. Theupregulation of both CD107a and CD107b on the surface of tumor cell lines has beenassociated with their enhanced metastatic potential, where they may increase adhesion toextracellular matrix and endothelium. (Ref. 1-7)
UniProt P13473
Research Area CD Antigens, Surface Receptors of Immune Cells
Application Notes Flow Cytometry: 10 µL/10e6 cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Buffer PBS containing 0.09% Sodium Azide as preservative.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or in (aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Expiry Date 12 months
Background publications Febbraio, Silverstein: "Identification and characterization of LAMP-1 as an activation-dependent platelet surface glycoprotein." in: The Journal of biological chemistry, Vol. 265, Issue 30, pp. 18531-7, 1990 (PubMed).

Chen, Cha, Yuksel et al.: "Isolation and sequencing of a cDNA clone encoding lysosomal membrane glycoprotein mouse LAMP-1. Sequence similarity to proteins bearing onco-differentiation antigens." in: The Journal of biological chemistry, Vol. 263, Issue 18, pp. 8754-8, 1988 (PubMed).

Sawada, Tsuboi, Fukuda: "Differential E-selectin-dependent adhesion efficiency in sublines of a human colon cancer exhibiting distinct metastatic potentials." in: The Journal of biological chemistry, Vol. 269, Issue 2, pp. 1425-31, 1994 (PubMed).

Sawada, Lowe, Fukuda: "E-selectin-dependent adhesion efficiency of colonic carcinoma cells is increased by genetic manipulation of their cell surface lysosomal membrane glycoprotein-1 expression levels." in: The Journal of biological chemistry, Vol. 268, Issue 17, pp. 12675-81, 1993 (PubMed).

Sawada, Jardine, Fukuda: "The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes." in: The Journal of biological chemistry, Vol. 268, Issue 12, pp. 9014-22, 1993 (PubMed).

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