Cytokeratin 19 antibody (C-Term)

Catalog No. ABIN371616

This anti-Cytokeratin 19 antibody is a Mouse Monoclonal antibody detecting Cytokeratin 19 in WB, IHC (fro) and EIA. Suitable for Mammalian.

Quick Overview for Cytokeratin 19 antibody (C-Term) (ABIN371616)

Target: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Reactivity: Mammalian

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 19 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: SB39g

Product Details anti-Cytokeratin 19 Antibody

Binding Specificity: C-Term

Specificity: This antibody reacts specifically specifically with cytokeratin 19 and recombinant C-terminal keratin 19. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers. (Ref.8,9)

Characteristics: Synonyms: Cytokeratin-19, Keratin-19, KRT19, CK19, K19, Keratin type I cytoskeletal 19

Purification: Purified

Immunogen: Recombinant C-terminal keratin 19.

Isotype: IgG2a

Application Details

Application Notes: ELISA. Western Blot: 1/2,000-1/4,000. Immunohistochemistry (Acetone-Fixed, Frozen Tissue Sections): 10 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: 100 mM Borate buffered saline, pH 8.0 without preservatives or amine-containing buffer salts.

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Cytokeratin 19

Target: Cytokeratin 19 (KRT19) (Keratin 19 (KRT19))

Alternative Name: Cytokeratin 19

Background: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30 % sequence homology. (Ref.1-5) Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin, is found in many simple and some non-keratinizing stratified squamous epithelia, and is often co-expressed with keratin 7.(Ref.6,7) Cytokeratin 19 has been implicated as a marker for stem cells in some tissues, such as hair follicles in the skin.Synonyms: CK19, Cytokeratin-19, K19, KRT19, Keratin type I cytoskeletal 19, Keratin-19

Gene ID: 3880

UniProt: P08727