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GABBR1 antibody (pSer923)
GABBR1
Reactivity: Human, Rat, Mouse, Cow, Non-Human Primate
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-GABBR1 Antibody
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Target
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GABBR1
(gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
Binding Specificity
All epitopes for GABBR1 antibodies
pSer923
Reactivity
All reactivities for GABBR1 antibodies
Human, Rat, Mouse, Cow, Non-Human Primate
Host
All hosts for GABBR1 antibodies
Rabbit
Clonality
All clonalities for GABBR1 antibodies
Polyclonal
Conjugate
All conjugates for GABBR1 antibodies
This GABBR1 antibody is un-conjugated
Application
All applications for GABBR1 antibodies
Western Blotting (WB)
Specificity
Specific for ~102k GABAB R1 phosphorylated at Ser923. Immunolabeling of the GABAB R1 band is completely blocked by lambda-phosphatase treatment.
Cross-Reactivity (Details)
Species reactivity (expected):Human, Bovine, Mouse and non-Human Primates. Species reactivity (tested):Rat.
Purification
Sequential Chromatography on phospho- and dephospho-peptide affinity columns.
Immunogen
Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser923 of GABAB R1
Isotype
IgG
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Alternatives
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Application Details
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Application Notes
Western Blot: 1/1000. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Format
Liquid
Buffer
10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg/mL BSA and 50 % Glycerol.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody undiluted (in aliquots) at-20 °C.
Target Details for GABBR1
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Target
GABBR1
(gamma-aminobutyric Acid (GABA) B Receptor, 1 (GABBR1))
Alternative Name
GABBR1 (GABBR1 Products )
Synonyms
GABABR1 antibody, GABBR1-3 antibody, GB1 antibody, GPRC3A antibody, dJ271M21.1.1 antibody, dJ271M21.1.2 antibody, gabbr1 antibody, GABBR1 antibody, GABA(B)R1 antibody, GABAB1 antibody, GABAbR1 antibody, bM573K1.1 antibody, gamma-aminobutyric acid type B receptor subunit 1 antibody, gamma-aminobutyric acid (GABA) B receptor, 1a antibody, gamma-aminobutyric acid (GABA) B receptor, 1 antibody, GABBR1 antibody, gabbr1a antibody, gabbr1 antibody, Gabbr1 antibody
Background
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Phosphorylation enhances GABAB receptor effector coupling (Couve et al., 2004). Phosphorylation of Ser923 is thought to be important in the regulation of GABAB receptor function.Synonyms: GABA-B receptor 1, GABA-B-R1, GABA-BR1, GABABR1, GPRC3A, Gamma-aminobutyric acid type B receptor subunit 1, Gb1
Gene ID
81657
NCBI Accession
NP_112290
UniProt
Q9Z0U4
Pathways
Positive Regulation of Peptide Hormone Secretion , cAMP Metabolic Process
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