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Details for Product No. ABIN374066

Suppressor of Cytokine Signaling 3 (SOCS3) (C-Term) antibody

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Antigen
Synonyms
SSI-3, SOCS-3, Cis3, Ef10, Ssi3, Cish3, EF-10, Socs-3, Ssi-3, ATOD4, CIS3, SSI3, socs3, fj09e12, zgc:56537, wu:fj09e12, MGC64393, MGC75749, xsocs3, MGC81248, atod4, cis3, cish3, socs-3, ssi-3, ssi3, S ... show more
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374066
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence from the C Terminus of the protein sequence according to NP_003946.3. Genename: SOCS3
Sequence C-PIREFLDQYDAPL
Specificity This antibody detects SOCS3 at C-term.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name SOCS3 / CIS3
Background Accumulating evidence demonstrates that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules Termed SOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have been recognized, they are SOCS-1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an N-terminal region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STAT-induced transcriptional mechanism. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways.
Alternate names: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3
Gene ID 9021
NCBI Accession NP_003946.3
UniProt O14543
Application Notes ELISA: Limit dilution: 1/16000. Western Blot: 4-6 µg/ml. Approx 24 kDa band observed in MOLT-4 lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH 7.3 containing 0.02% Sodium Azide and 0.5% BSA
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Roberts, Robb, Rakar et al.: "Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 98, Issue 16, pp. 9324-9, 2001 (PubMed).

Alternatives for antigen "Suppressor of Cytokine Signaling 3 (SOCS3)", type "Antibodies"
Hosts (57), (56), (7)
Reactivities (105), (36), (28), (14), (13), (13), (12), (1)
Applications (92), (43), (31), (23), (20), (16), (10), (4), (4), (4), (3), (1), (1)
Conjugates (7), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (9), (4), (3), (3), (2), (1), (1)
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