Search, Find and Buy Antibodies, ELISA Kits and Proteins.
Loading Loading
Order hotline:
phone +1 404 474 4654
fax +1 888 205 9894 (TF)
Details for Product No. ABIN374168

Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2) (C-Term) antibody

Request
Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms ALS2CR6, ALSJ, IAHSP, PLSJ, 3222402C23Rik, 9430073A21Rik, Als2cr6, Alsin, mKIAA1563, als2, si:dkey-33m14.1
Epitope
»Alternatives C-Term
Reactivity
»Alternatives Cow (Bovine), Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
Host
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 1 reference available
Catalog no. ABIN374168
Quantity 0.1 mg
Price
346.50 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide from C Terminus of the protein sequence according to NP_065970.2 Genename: ALS2
Sequence LKACYYQIQREKLN
Specificity This antibody detects Alsin / ALS2 at C-term.
Purification Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
Alternative Name Alsin / ALS2
Background ALS2 specifically binds to, and functions as a guanine nucleotide exchange factor (GEF) for the small GTPase RAB5. ALS2 contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Loss of ALS2 function might underlie neuronal dysfunction and degeneration in a number of motor neuron diseases.
Alternate names: ALS2CR6, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 6 protein, Amyotrophic lateral sclerosis protein 2, KIAA1563
Gene ID 57679
NCBI Accession NP_065970.2
UniProt Q96Q42
Application Notes Peptide ELISA: Limit dilution 1: 8000. Immunohistochemistry: 3-5 µg/ml. In paraffin embedded Human Cortex shows pixulatecytoplasm staining in some neuronal cells. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
Expiry Date 12 months
Background publications Yang, Hentati, Deng et al.: "The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis." in: Nature genetics, Vol. 29, Issue 2, pp. 160-5, 2001 (PubMed).

Alternatives for antigen "Amyotrophic Lateral Sclerosis 2 (Juvenile) (ALS2)", type "Antibodies"
Hosts (29), (9), (5)
Reactivities (39), (21), (19), (15), (13), (12)
Applications (23), (19), (11), (10), (6), (2), (1), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (9), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Beacon