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A Disintegrin and Metallopeptidase Domain 8 (ADAM8) (C-Term) antibody

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Synonyms adam8, reprolysin, si:zc217g15.7, zgc:64059, ADAM8, CD156, CD156a, E430039A18Rik, MS2, Adam8
(2), (2), (2), (2), (1), (1), (1)
(8), (2), (2)
(8), (2)
Enzyme Immunoassay (EIA), Western Blotting (WB)
(8), (3), (2), (2), (2), (1)
Pubmed 1 reference available
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Quantity 0.1 mg
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Immunogen Peptide from C Terminus of the protein sequence according to NP_001100.3, NP_001157962.1. Genename: ADAM8
Specificity This antibody is expected to recognise isoform 1 and 3 (NP_001100.3 and NP_001157962.1).
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name CD156a / ADAM8 (ADAM8 Antibody Abstract)
Background Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.Synonyms: Cell surface antigen MS2, Disintegrin and metalloproteinase domain-containing protein 8, MS2
Molecular Weight 88.8 kDa according to NP_001100.3.
Gene ID 101
NCBI Accession NP_001100
UniProt P78325
Research Area Proteases, Extracellular Matrix
Application Notes Peptide ELISA: Limit dilution 1: 1000. Western blot: 1-3 μg/mL. Approx 90 kDa band seen in Human Brain lysate.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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 image for anti-A Disintegrin and Metallopeptidase Domain 8 (ADAM8) (C-Term) antibody (ABIN374195) anti-A Disintegrin and Metallopeptidase Domain 8 (ADAM8) (C-Term) antibody
Background publications Yoshiyama, Higuchi, Kataoka et al.: "CD156 (human ADAM8): expression, primary amino acid sequence, and gene location." in: Genomics, Vol. 41, Issue 1, pp. 56-62, 1997 (PubMed).

Catalog No. ABIN374195
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