Verified
ADAM8
Reactivity: Human
WB, ELISA
Host: Goat
Polyclonal
unconjugated
Application Notes
Peptide ELISA: Limit dilution 1: 1000. Western blot: 1-3 μg/mL. Approx 90 kDa band seen in Human Brain lysate. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
CD156 antibody, MS2 antibody, CD156a antibody, E430039A18Rik antibody, adam8 antibody, reprolysin antibody, si:zc217g15.7 antibody, zgc:64059 antibody, ADAM8 antibody, RGD1566394 antibody, ADAM metallopeptidase domain 8 antibody, a disintegrin and metalloproteinase domain 8 antibody, a disintegrin and metallopeptidase domain 8 antibody, ADAM metallopeptidase domain 8a antibody, ADAM8 antibody, LOC100304737 antibody, Adam8 antibody, adam8a antibody, adam8 antibody
Background
Members of ADAM family are cell surface proteins with a unique structure possessing both potential adhesion and protease domains. The extracellular region of ADAM8 shows significant amino acid sequence homology to hemorrhagic snake venom proteins, including the metalloprotease and disintegrin domains. The expression of ADAM8 is upregulated by retinoic acid and vitamin D3. The function of ADAM8 is still poorly understood. ADAM8 has been shown to stimulate osteoclasts, and to be produced by bone marrow cultures stimulated by vitamin-D. ADAM8 is involved in protein processing at the cell surface and is also thought to act as a leukocyte differentiation marker.Synonyms: Cell surface antigen MS2, Disintegrin and metalloproteinase domain-containing protein 8, MS2