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ING2 antibody (C-Term)

ING2 Reactivity: Human, Cow WB Host: Goat Polyclonal unconjugated
Catalog No. ABIN374223
  • Target See all ING2 Antibodies
    ING2 (Inhibitor of Growth Family, Member 2 (ING2))
    Binding Specificity
    • 7
    • 6
    • 6
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 33
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Cow
    Host
    • 27
    • 5
    • 1
    Goat
    Clonality
    • 29
    • 4
    Polyclonal
    Conjugate
    • 16
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ING2 antibody is un-conjugated
    Application
    • 25
    • 19
    • 3
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequence
    C-DKSTEKTKKD RRSR
    Specificity
    This antibody detetcs ING2 / ING1L at C-term.
    Cross-Reactivity (Details)
    Species reactivity (expected):CowSpecies reactivity (tested):Human
    Purification
    Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
    Immunogen
    Peptide from C Terminus of the protein sequence according to NP_001555.1. Genename: ING2
    Top Product
    Discover our top product ING2 Primary Antibody
  • Application Notes
    Pedeux et al, ING2 regulates the onset of replicative senescence by induction ofp300-dependent p53 acetylation. Mol Cell Biol.2005 Aug,25(15): 6639-48. PMID: 16024799
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
  • Target
    ING2 (Inhibitor of Growth Family, Member 2 (ING2))
    Alternative Name
    ING2 / ING1L (ING2 Products)
    Synonyms
    ING1L antibody, p33ING2 antibody, 2810011M06Rik antibody, Ing1l antibody, Ing2b antibody, P33ING2 antibody, ING2 antibody, INGX antibody, wu:fe11c08 antibody, zgc:92346 antibody, ING1Lp antibody, ing2 antibody, xing2 antibody, inhibitor of growth family member 2 antibody, inhibitor of growth family, member 2 antibody, inhibitor of growth family member 2 S homeolog antibody, inhibitor of growth family member 2 L homeolog antibody, ING2 antibody, Ing2 antibody, ing2.S antibody, ing2 antibody, ing2.L antibody
    Background
    This protein is similar to ING1, a tumor suppressor protein that can bind TP53, inhibit cell growth, and induce apoptosis. This protein binds phosphoinositides (PtdInPs) at its plant homeodomain (PHD) domain and it acts as a PtdInPs receptor. PtdInPs binding regulates the ability of this protein to activate TP53 and TP53-dependent apoptosis.Synonyms: Inhibitor of growth 1-like protein, Inhibitor of growth protein 2, p33ING2
    Gene ID
    3622
    NCBI Accession
    NP_001555
    UniProt
    Q9H160
    Pathways
    Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
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