ING2 antibody (C-Term)
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- Target See all ING2 Antibodies
- ING2 (Inhibitor of Growth Family, Member 2 (ING2))
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Binding Specificity
- C-Term
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Reactivity
- Human, Cow
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Host
- Goat
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Clonality
- Polyclonal
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Conjugate
- This ING2 antibody is un-conjugated
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Application
- Western Blotting (WB)
- Sequence
- C-DKSTEKTKKD RRSR
- Specificity
- This antibody detetcs ING2 / ING1L at C-term.
- Cross-Reactivity (Details)
- Species reactivity (expected):CowSpecies reactivity (tested):Human
- Purification
- Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide
- Immunogen
- Peptide from C Terminus of the protein sequence according to NP_001555.1. Genename: ING2
- Top Product
- Discover our top product ING2 Primary Antibody
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- Application Notes
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Pedeux et al, ING2 regulates the onset of replicative senescence by induction ofp300-dependent p53 acetylation. Mol Cell Biol.2005 Aug,25(15): 6639-48. PMID: 16024799
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
- Preservative
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.
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- Target
- ING2 (Inhibitor of Growth Family, Member 2 (ING2))
- Alternative Name
- ING2 / ING1L (ING2 Products)
- Synonyms
- ING1L antibody, p33ING2 antibody, 2810011M06Rik antibody, Ing1l antibody, Ing2b antibody, P33ING2 antibody, ING2 antibody, INGX antibody, wu:fe11c08 antibody, zgc:92346 antibody, ING1Lp antibody, ing2 antibody, xing2 antibody, inhibitor of growth family member 2 antibody, inhibitor of growth family, member 2 antibody, inhibitor of growth family member 2 S homeolog antibody, inhibitor of growth family member 2 L homeolog antibody, ING2 antibody, Ing2 antibody, ing2.S antibody, ing2 antibody, ing2.L antibody
- Background
- This protein is similar to ING1, a tumor suppressor protein that can bind TP53, inhibit cell growth, and induce apoptosis. This protein binds phosphoinositides (PtdInPs) at its plant homeodomain (PHD) domain and it acts as a PtdInPs receptor. PtdInPs binding regulates the ability of this protein to activate TP53 and TP53-dependent apoptosis.Synonyms: Inhibitor of growth 1-like protein, Inhibitor of growth protein 2, p33ING2
- Gene ID
- 3622
- NCBI Accession
- NP_001555
- UniProt
- Q9H160
- Pathways
- Chromatin Binding, Autophagy, Negative Regulation of intrinsic apoptotic Signaling
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