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Details for Product No. ABIN374334

Forkhead Box A1 (FOXA1) (C-Term) antibody

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HNF3A, TCF3A, Hnf3a, Tcf3a, Hnf-3a, Tcf-3a, fkd7, forkhead-7, HNF-3a, HNF3-alpha, HNF3alpha, fkh2, foxa1, hnf3a, tFoxA1, tcf3a, FoxA4a, XFD-1, fkh1, pintallavis, xfkh1, xkfh-1, xfkh2, fkh, FOXA1, Ci-f ... show more
»Alternatives C-Term
»Alternatives Cow (Bovine), Human, Mouse (Murine), Pig (Porcine), Rat (Rattus)
Clonality Polyclonal
»Alternatives Chromatin Immunoprecipitation (ChIP), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Pubmed 8 references available
Catalog no. ABIN374334
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 8 Business Days
Immunogen Peptide from C-Terminus of the protein sequence according to NP_004487.2 Genename: FOXA1
Specificity This antibody detects FOXA1. Species Reactivity: Tested: Human, Mouse. Expected from sequence similarity: Rat, Pig, Cow.
Purification Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide
Alternative Name FOXA1 / TCF3A
Background FOXA1 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.
Alternate names: Forkhead box protein A1, HNF-3-alpha, HNF-3A, HNF3A, Hepatocyte nuclear factor 3-alpha, TCF-3A, Transcription factor 3A
Gene ID 3169
NCBI Accession NP_004487.2
UniProt P55317
Application Notes Peptide ELISA: Limit dilution 1/16000. Western blot: 0.2-0.6 µg/ml. Approx 50kDa band observed in Human lysates of cell lineHepG2 (calculated MW of 49.1kDa according to NP_004487.2). An additional band ofunknown identity was also consistently observed at 35kDa. This band was successfullyblocked by incubation with the immunising peptide. Immunohistochemistry: 5-10 µg/ml. In paraffin embedded Human Prostate shows nuclear staining of secretory cells. Anonymous customers used this product successfully in ChIP with MCF7. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer Tris buffered saline, pH~7.3 0.02% Sodium Azide 0.5% BSA
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8°C for one month or (in aliquots) at -20°C.
Expiry Date 12 months
Background publications Nguyen, Cho, Stratton et al.: "Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene." in: Molecular and cellular biology, Vol. 25, Issue 6, pp. 2147-57, 2005 (PubMed).

Carroll, Liu, Brodsky et al.: "Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1." in: Cell, Vol. 122, Issue 1, pp. 33-43, 2005 (PubMed).

Eeckhoute, Carroll, Geistlinger et al.: "A cell-type-specific transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer." in: Genes & development, Vol. 20, Issue 18, pp. 2513-26, 2006 (PubMed).

Lupien, Eeckhoute, Meyer et al.: "FoxA1 translates epigenetic signatures into enhancer-driven lineage-specific transcription." in: Cell, Vol. 132, Issue 6, pp. 958-70, 2008 (PubMed).

Eeckhoute, Lupien, Meyer et al.: "Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers." in: Genome research, Vol. 19, Issue 3, pp. 372-80, 2009 (PubMed).

Hua, Kittler, White: "Genomic antagonism between retinoic acid and estrogen signaling in breast cancer." in: Cell, Vol. 137, Issue 7, pp. 1259-71, 2009 (PubMed).

McMullin, Dobi, Mutton et al.: "A FOXA1-binding enhancer regulates Hoxb13 expression in the prostate gland." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 1, pp. 98-103, 2010 (PubMed).

Taube, Allton, Duncan et al.: "Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells." in: The Journal of biological chemistry, Vol. 285, Issue 21, pp. 16135-44, 2010 (PubMed).

Alternatives for antigen "Forkhead Box A1 (FOXA1)", type "Antibodies"
Hosts (39), (31), (10)
Reactivities (78), (14), (9), (5), (3), (3), (2), (2), (1)
Applications (62), (47), (43), (17), (6), (3), (2), (2), (1), (1)
Epitopes (14), (8), (6), (4), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)