Peptide ELISA: Limit dilution 1: 2000. Western blot: 0.5 μg/mL. Approx 60-65 kDa band observed in Human Liver lysate (predictedMW of 55 kDa according to NP_068556 and NP_710141). Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
FOXA2 is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporatic cases of maturity-onset diabetes of the young. Two transcript variants encoding the same protein have been identified for this gene.Synonyms: HNF-3-beta, HNF-3B, Hepatocyte nuclear factor 3-beta, TCF3B, Transcription factor 3B