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IRAK4 antibody (N-Term)

IRAK4 Reactivity: Human, Mouse WB, EIA Host: Goat Polyclonal unconjugated
Catalog No. ABIN374511
  • Target See all IRAK4 Antibodies
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Binding Specificity
    • 37
    • 16
    • 15
    • 11
    • 8
    • 8
    • 8
    • 7
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivity
    • 115
    • 67
    • 27
    • 16
    • 14
    • 13
    • 3
    • 3
    • 2
    • 2
    • 1
    Human, Mouse
    Host
    • 109
    • 11
    • 1
    Goat
    Clonality
    • 108
    • 13
    Polyclonal
    Conjugate
    • 53
    • 8
    • 7
    • 7
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    This IRAK4 antibody is un-conjugated
    Application
    • 112
    • 52
    • 37
    • 26
    • 18
    • 16
    • 15
    • 10
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    Sequence
    NKPITPSTYV RC
    Specificity
    This antibody recognizes IRAK4 at N-term.
    Cross-Reactivity (Details)
    Species reactivity (expected):Mouse.
    Species reactivity (tested):Human.
    Purification
    Affinity Chromatography
    Immunogen
    Peptide with sequence from the N Terminus of the protein sequence according to NP_057207.2, NP_001107654.1. Genename: IRAK4
    Top Product
    Discover our top product IRAK4 Primary Antibody
  • Application Notes
    Peptide ELISA: 1/32000. Western Blot: 1 - 3 μg/mL.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Restrictions
    For Research Use only
  • Concentration
    0.5 mg/mL
    Buffer
    Tris saline containing 0.02 % Sodium Azide, pH 7.3 with 0.5 % BSA
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))
    Alternative Name
    IRAK4 (IRAK4 Products)
    Synonyms
    zgc:55553 antibody, IRAK4 antibody, ipd1 antibody, irak-4 antibody, ny-ran-64 antibody, ny-ren-64 antibody, ren64 antibody, irak4 antibody, IPD1 antibody, IRAK-4 antibody, NY-REN-64 antibody, REN64 antibody, 8430405M07Rik antibody, 9330209D03Rik antibody, interleukin 1 receptor associated kinase 4 antibody, interleukin-1 receptor-associated kinase 4 antibody, IRAK4 antibody, irak4 antibody, Irak4 antibody
    Background
    Interleukin 1 (IL1) and lipopolysaccharide (LPS) induces cellular responses through IL1 receptor (IL1R) and Toll like receptors (TLR). IL1R associated kinases (IRAK, IRAK2, and IRAKM) regulate the activation of NF-kB and MAP kinase (MAPK) by IL1R/TLR. A novel member in the IRAK/Pelle family was recently identified and designated IRAK4. Overexpression of IRAK4 activates NF-kB and MAPK pathways. IRAK4 interacts with and phosphorylates IRAK1. IRAK4 deficient animals are completely resistant to the challenge with LPS. Animals and humans lacking IRAK4 are impaired in their responses to viral and bacterial challenges. Members in IRAK/Pelle family play a central role in IL1R/TLR mediated inflammatory responses and in innate immunity.Synonyms: IRAK-4, Interleukin-1 receptor-associated kinase-like, NY-REN-64
    Gene ID
    51135
    NCBI Accession
    NP_001107654
    UniProt
    Q9NWZ3
    Pathways
    NF-kappaB Signaling, TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades
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