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Details for Product No. ABIN374587

Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) (Internal Region) antibody

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Synonyms CD314, D12S2489E, KLR, NKG2-D, NKG2D, Nkrp2, KLRK1, Nkg2d, D6H12S2489E
»Alternatives Internal Region
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Clonality Polyclonal
»Alternatives Un-conjugated
»Alternatives Western Blotting (WB)
Pubmed 1 reference available
Catalog no. ABIN374587
Quantity 0.1 mg
346.50 $   Plus shipping costs $45.00
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Immunogen Peptide with sequence C-KVYSKEDQDLLK, from the internal region of the protein sequence
Specificity This antibody reacts to CD314. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat.
Purification Affinity chromatography
Alternative Name CD314 / KLRK1
Background NKG2D is a C-type lectin-like activating receptor which is expressed on most natural killer (NK) cells, CD8 T cells and gamma delta T cells. NKG2D forms homodimers that signal through an associated DAP10 adaptor protein. Ligands of NKG2D include MICA, MICB and UL16 binding protein (ULBP), which are inducibly expressed. Ligand binding to NKG2D results in NK cell activation and potent costimulation of effector T cells.
Alternate names: D12S2489E, Killer cell lectin-like receptor subfamily K member 1, NK cell receptor D, NKG2-D type II integral membrane protein, NKG2-D-activating NK receptor, NKG2D
Gene ID 22914
NCBI Accession 9606
UniProt P26718
Application Notes Peptide ELISA: 1/32000. Western Blot: 0.1 - 0.3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Hayakawa, Smyth: "Innate immune recognition and suppression of tumors." in: Advances in cancer research, Vol. 95, pp. 293-322, 2006 (PubMed).

Alternatives for antigen "Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1)", type "Antibodies"
Hosts (46), (46), (32), (27), (8), (1)
Reactivities (93), (81), (19)
Applications (135), (29), (28), (20), (13), (10), (9), (4), (4), (4), (3), (1)
Conjugates (20), (17), (13), (7), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (7), (4)