GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (Internal Region) antibody

Details for Product No. ABIN374593
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Antigen
Synonyms GATA1, gata-1, Gata1, si:dkeyp-77f7.5, Gata-1, Gf-1, eryf1, Eryf1, ERYF1, GATA-1, GF-1, GF1, NF-E1, NFE1, XLANP, XLTDA, XLTT
Epitope
Internal Region
(39), (37), (13), (12), (4), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(184), (109), (106), (15), (13), (12), (2), (1)
Host
Goat
(157), (26), (5)
Clonality
Polyclonal
Conjugate
Un-conjugated
(4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4)
Application
Western Blotting (WB)
(139), (49), (48), (41), (40), (25), (22), (12), (2)
Pubmed 1 reference available
Quantity 0.1 mg
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Catalog No. ABIN374593
357.50 $
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Immunogen Peptide with sequence C-DAEAYRHSPVFQ, from the internal region of the protein sequence
Specificity This antibody reacts to GATA1. Species Reactivity: Tested: Human. Expected from sequence similarity: Mouse, Rat, Canine, Bovine.
Purification Affinity chromatography
Alternative Name GATA1
Background GATA1 (Globin transcription factor 1) is a Cys2/Cys2 zinc finger DNA binding protein that is expressed primarily in erythroid, megakaryocytic, mast cells and eosinophilic cells. It belongs to the GATA family of transcription factors. GATA1 is a transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. The protein also plays an important role in erythroid development by regulating the switch from fetal hemoglobin production to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. Acquired somatic mutations in GATA1 occur in virtually all children with Down's Syndrome, congenital transient myeloproliferative syndrome (TMD) and acute megakaryocytic leukemia.
Alternate names: ERYF1, Eryf1, Erythroid transcription factor, GATA-1, GATA-1, GATA-binding factor 1, GF-1, GF1, NF-E1 DNA-binding protein
Gene ID 2623
NCBI Accession NP_002040
UniProt P15976
Research Area Organogenesis, Hematopoietic Progenitors, Transcription Factors
Application Notes Peptide ELISA: 1/16000. Western Blot: 0.3 - 1.0 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (Internal Region) antibody anti-GATA Binding Protein 1 (Globin Transcription Factor 1) (GATA1) (Internal Region) antibody
Background publications Li, Godinho, Klusmann et al.: "Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1." in: Nature genetics, Vol. 37, Issue 6, pp. 613-9, 2005 (PubMed).

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