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Phosphatidylethanolamine Binding Protein 1 (PEBP1) (Internal Region) antibody

Details for Product No. ABIN374748, Supplier: Login to see
Antigen
  • BcDNA:LP12095
  • CG18594
  • Dmel\\CG18594
  • PEBP1
  • T2
  • pbp
  • hcnp
  • pebp
  • rkip
  • HCNP
  • HCNPpp
  • PBP
  • PEBP
  • PEBP-1
  • RKIP
  • Pbp
  • Rkip
  • Pbp1
  • Pbpr
  • B-TG1
  • Beta-TG
  • CTAP-III
  • CTAP3
  • CTAPIII
  • CXCL7
  • LA-PF4
  • LDGF
  • MDGF
  • NAP-2
  • SCYB7
  • TC1
  • TC2
  • TGB
  • TGB1
  • THBGB
  • THBGB1
Epitope
Internal Region
37
29
23
11
5
4
3
2
2
2
2
1
1
1
1
1
1
Reactivity
Dog (Canine), Human, Mouse (Murine), Rat (Rattus)
143
44
38
9
8
3
2
2
2
1
1
1
1
Host
Goat
103
39
20
1
Clonality
Polyclonal
Conjugate
Un-conjugated
6
6
6
6
6
6
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
145
102
72
28
8
7
7
5
2
2
2
1
Supplier
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Immunogen Peptide with sequence C-DPDAPSRKDPKYRE, from the internal region of the protein sequence according to NP_002558.1. Genename: PEBP1
Specificity This antibody reacts to PEBP1/RKIP.
Cross-Reactivity (Details) Species reactivity (expected):Mouse, Rat and Canine.
Species reactivity (tested):Human.
Purification Ammonium sulphate precipitation followed by antigen Affinity Chromatography using the immunizing peptide.
Alternative Name PEBP1 / RKIP (PEBP1 Antibody Abstract)
Background PBP, also known as RKIP (RAF kinase inhibitor protein), binds ATP, opioids and phosphatidylethanolamine. PBP is able to regulate Aurora kinase B expression and the spindle checkpoint through interaction with the RAF1/MEK/ERK cascade. PBP is able to bind to RAF1 and MEK and competitively disrupt the interaction between these proteins. PBP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. It increases the production of choline acetyltransferase but not acetylcholinesterase. PBP has been implicated as a suppressor of metastasis.Synonyms: HCNPpp, PBP, PEBP, PEBP-1, Phosphatidylethanolamine-binding protein 1, Prostatic-binding protein, Raf kinase inhibitor protein
Gene ID 5037
NCBI Accession NP_002558
UniProt P30086
Pathways
Application Notes Peptide ELISA: Detection Limit: 1/128000. Western blot: 0.01-0.03 μg/mL. Approx 21 kDa band observed in Human Prostate lysates(calculated MW of 21.1 kDa according to NP_002558.1). Immunohistochemistry: 2-5 μg/mL. In paraffin embedded Adrenal Gland shows strongstinaing of secretory cells.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0.5 mg/mL
Buffer Tris saline, pH 7.3 containing 0.02 % Sodium Azide as preservative and 0.5 % BSA as stabilizer.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Phosphatidylethanolamine Binding Protein 1 (PEBP1) (Internal Region) antibody (ABIN374748) anti-Phosphatidylethanolamine Binding Protein 1 (PEBP1) (Internal Region) antibody
 image for anti-Phosphatidylethanolamine Binding Protein 1 (PEBP1) (Internal Region) antibody (ABIN374748) anti-Phosphatidylethanolamine Binding Protein 1 (PEBP1) (Internal Region) antibody (Image 2)
Background publications Yeung, Seitz, Li et al.: "Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP." in: Nature, Vol. 401, Issue 6749, pp. 173-7, 1999 (PubMed).