DISC1 antibody (Internal Region)

Catalog No. ABIN374852

The Goat Polyclonal anti-DISC1 antibody is suitable to detect DISC1 in samples from Human. It has been validated for WB.

Quick Overview for DISC1 antibody (Internal Region) (ABIN374852)

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This DISC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-DISC1 Antibody

Binding Specificity: Internal Region

Specificity: This antibody reacts to DISC1. This antibody is expected to recognise isoforms L and Lv only.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-HSEDKRKTPLKVLE, from the internal region of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/128000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for DISC1

Target: DISC1 (Disrupted in Schizophrenia 1 (DISC1))

Alternative Name: DISC1

Background: DISC1 (disrupted in schizophrenia 1) is a protein with multiple coiled coil motifs which is located in the nucleus, cytoplasm and mitochondria. DISC1 is a multifunctional protein that is involved in neurite outgrowth and cortical development, through its interaction with proteins of the centrosome and cytoskeletal system, and is implicated in schizophrenia. Regions of the primate brain which express DISC1, including the hippocampus, lateral septum, amygdala, cerebral cortex, cerebellum and paraventricular hypothalamus, are reported to be involved in schizophrenia in humans.Synonyms: DISC-1, Disrupted in schizophrenia 1 protein, KIAA0457

Gene ID: 27185

NCBI Accession: NP_001012975

UniProt: Q9NRI5

Pathways: Regulation of Cell Size