AKR1B10 antibody (C-Term)

Catalog No. ABIN374920

Product Details anti-AKR1B10 Antibody

Target: AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This AKR1B10 antibody is un-conjugated

Application: Western Blotting (WB)

Specificity: This antibody reacts to AKR1B10.

Purification: Affinity chromatography

Immunogen: Peptide with sequence C-QSSHLEDYPFDAE, from the C Terminus of the protein sequence

Application Details

Application Notes: Peptide ELISA: 1/8000. Western Blot: 0.03 - 0.1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0,5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-AKR1B10 antibody (ABIN374920)

Díez-Dacal, Gayarre, Gharbi, Timms, Coderch, Gago, Pérez-Sala: "Identification of aldo-keto reductase AKR1B10 as a selective target for modification and inhibition by prostaglandin A(1): implications for antitumoral activity." in: Cancer research, Vol. 71, Issue 12, pp. 4161-71, (2011) (PubMed).

Target Details for AKR1B10

Target: AKR1B10 (Aldo-Keto Reductase Family 1, Member B10 (Aldose Reductase) (AKR1B10))

Alternative Name: AKR1B10 (AKR1B10 Products)

Synonyms: AKR1B11 antibody, AKR1B12 antibody, ALDRLn antibody, ARL-1 antibody, ARL1 antibody, HIS antibody, HSI antibody, 2310005E10Rik antibody, Akr1b16 antibody, AKR antibody, AKR1B10 antibody, Akr1b10 antibody, aldo-keto reductase family 1 member B10 antibody, aldo-keto reductase family 1, member B10 (aldose reductase) antibody, aldo-keto reductase family 1 member B10-like 2 antibody, AKR1B10 antibody, Akr1b10 antibody, AKR1B10L2 antibody, LOC100585902 antibody, LOC100723118 antibody, LOC101107697 antibody

Background: ARK1B10 is a NADPH dependant enzyme with an ability to efficiently reduce aliphatic and aromatic aldehydes. A 316 A.A protein, AKR1B10 is a highly efficient retinal reductase constituting the first cytosolic NADP (H) dependent retinal reductase described in humans and is characterized by the presence of a novel NADP binding motif. Due to its ability to convert glucose to sorbitol, AKR1B10 may have a role in development of secondary diabetic complications. It is abundantly expressed in adrenal gland, small intestine and colon, with lower levels in liver, thymus, prostate, testis, and skeletal muscle and its levels are up regulated in certain cancers such as hepatocellular carcinoma.Synonyms: AKR1B11, ARL-1, Aldo-keto reductase family 1 member B10, Aldose reductase-like, Aldose reductase-related protein, Small intestine reductase

Gene ID: 57016, 9606

UniProt: O60218