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Glucokinase (Hexokinase 4) Regulator (GCKR) (N-Term) antibody

Details for Product No. ABIN375154, Supplier: Login to see
Antigen
  • FGQTL5
  • GKRP
  • GLRE
  • gckr
  • 4432415E19Rik
  • GCKR
  • KHS
  • MAPKKKK5
Epitope
N-Term
13
5
5
5
4
3
2
2
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
66
41
41
2
1
1
Host
Goat
57
13
8
Clonality
Polyclonal
Conjugate
Un-conjugated
5
4
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
54
36
13
11
8
5
5
4
Supplier
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Immunogen Peptide with sequence KRFQHVIETPEPGK -C, from the N-Terminus of the protein sequence
Specificity This antibody reacts to GCKR.
Cross-Reactivity (Details) Species reactivity (expected):Human.
Species reactivity (tested):Mouse, Rat.
Purification Affinity chromatography
Alternative Name GCKR (GCKR Antibody Abstract)
Background GCKR is a subfamily member of the SIS (Sugar ISomerase) family of proteins. It is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).Synonyms: GCKR, Glucokinase regulator, Glucokinase regulatory protein
Gene ID 2646, 9606
UniProt Q14397
Research Area Cancer, Atherosclerosis, Metabolism
Pathways
Application Notes Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Concentration 0,5 mg/mL
Buffer Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
 image for anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (N-Term) antibody (ABIN375154) anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (N-Term) antibody
Background publications Kathiresan, Melander, Guiducci et al.: "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans. ..." in: Nature genetics, Vol. 40, Issue 2, pp. 189-97, 2008 (PubMed).