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Glucokinase (Hexokinase 4) Regulator (GCKR) (N-Term) antibody

Details for Product No. ABIN375154
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Antigen
Synonyms FGQTL5, GKRP, GLRE, gckr, 4432415E19Rik, GCKR, KHS, MAPKKKK5
Epitope
N-Term
(3), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(52), (40), (39), (23), (11)
Host
Goat
(49), (6), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(38), (19), (19), (14), (5), (5), (3), (3), (1)
Pubmed 1 reference available
Quantity 0.1 mg
Shipping to United States (Change)
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Catalog No. ABIN375154
357.50 $
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Immunogen Peptide with sequence KRFQHVIETPEPGK -C, from the N-Terminus of the protein sequence
Specificity This antibody reacts to GCKR. Species Reactivity: Tested: Mouse, Rat. Expected from sequence similarity: Human.
Purification Affinity chromatography
Alternative Name GCKR
Background GCKR is a subfamily member of the SIS (Sugar ISomerase) family of proteins. It is a regulatory protein that inhibits glucokinase in liver and pancreatic islet cells by binding non-covalently to form an inactive complex with the enzyme. This gene is considered a susceptibility gene candidate for a form of maturity-onset diabetes of the young (MODY).
Alternate names: GCKR, Glucokinase regulator, Glucokinase regulatory protein
Gene ID 2646
NCBI Accession 9606
UniProt Q14397
Research Area Cancer, Atherosclerosis, Metabolism
Application Notes Peptide ELISA: 1/8000. Western Blot: 0.1 - 0.3 µg/ml. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 0,5 mg/mL
Buffer Tris buffered saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Supplier Images
anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (N-Term) antibody anti-Glucokinase (Hexokinase 4) Regulator (GCKR) (N-Term) antibody
Background publications Kathiresan, Melander, Guiducci et al.: "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans." in: Nature genetics, Vol. 40, Issue 2, pp. 189-97, 2008 (PubMed).

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