FGFR2 antibody (Internal Region)

Catalog No. ABIN375199

Product Details anti-FGFR2 Antibody

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Binding Specificity: Internal Region

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This FGFR2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to FGFR2.

Cross-Reactivity (Details): Species reactivity (expected):Mouse, Rat.
Species reactivity (tested):Human.

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography

Immunogen: Peptide with sequence C-GREKEITASPDY, from the internal region of the protein sequence

Application Details

Application Notes: ELISA: 1/64000. Western Blot: 0.3 - 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-FGFR2 antibody (ABIN375199)

McGrath, Lee, Buring, Hunter, De Vivo: "Novel breast cancer risk alleles and endometrial cancer risk." in: International journal of cancer, Vol. 123, Issue 12, pp. 2961-4, (2008) (PubMed).

Target Details for FGFR2

Target: FGFR2 (Fibroblast Growth Factor Receptor 2 (FGFR2))

Alternative Name: CD332 / FGFR-2 (FGFR2 Products)

Synonyms: FGFR2 antibody, FGFR2IIIb antibody, bek antibody, bfr-1 antibody, cd332 antibody, cek3 antibody, cfd1 antibody, ect1 antibody, fgfr-2 antibody, jws antibody, k-sam antibody, kgfr antibody, tk14 antibody, tk25 antibody, xfgfr2 antibody, DKFZp469H1521 antibody, BBDS antibody, BEK antibody, BFR-1 antibody, CD332 antibody, CEK3 antibody, CFD1 antibody, ECT1 antibody, JWS antibody, K-SAM antibody, KGFR antibody, TK14 antibody, TK25 antibody, AU043015 antibody, AW556123 antibody, Bek antibody, Fgfr-2 antibody, Fgfr-7 antibody, Fgfr7 antibody, KGFRTr antibody, svs antibody, FGF-R antibody, fgfr72IIIb antibody, FGFR antibody, fc56c05 antibody, wu:fc56c05 antibody, fibroblast growth factor receptor 2 antibody, fibroblast growth factor receptor 2 L homeolog antibody, FGFR2 antibody, LOC100084641 antibody, fgfr2 antibody, Fgfr2 antibody, fgfr2.L antibody

Background: Fibroblast growth factors (FGFs) are members of a large family of structurally related polypeptides that are potent physiological regulators of growth and differentiation for a wide variety of cells of mesodermal, ectodermal and endodermal origin. Four genes encoding for high affinity cell surface FGF receptors (FGFRs) have been identified: FGFR1, FGFR2, FGFR3 and FGFR4. FGFRs are members of the tyrosine kinase family of growth factor receptors. FGFR2 is highly expressed in developing human tissues including the brain, choroids plexus, lung etc.Synonyms: BEK, FGFR2, Fibroblast growth factor receptor 2, KGFR, KSAM, Keratinocyte growth factor receptor 2

Gene ID: 2263

NCBI Accession: NP_000132

UniProt: P21802

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Growth Factor Binding