The Rat Monoclonal anti-FCER2 antibody (Clone 2G8) (ABIN376377) specifically detects FCER2 in FACS, ELISA and IHC (fro).
The antibody is reactive with Mouse samples.
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Format
Liquid
Concentration
0.5 mg/mL
Buffer
Phosphate buffered saline, pH 7.4
Preservative
Azide free
Handling Advice
Each reagent is stable for the period shown on the bottle label if stored as directed.
Storage
4 °C
Storage Comment
2-8°C
Target
FCER2
(Fc Fragment of IgE, Low Affinity II, Receptor For (CD23) (FCER2))
Alternative Name
CD23
Background
The CD23 antigen is the low affinity IgE Fc receptor, which is a 49 kDa protein with 38 and 28 kDa fragments. It is expressed on most mature, conventional B cells (but not on peritoneal CD5 + B cells), and can also be found on the surface of T cells, macrophages and platelets. It is distinct from the high affinity IgE receptors found on basophils and mast cells, which mediate allergic reactions. The low affinity receptors are thought to play a role in isotype specific immunoregulation. The regulation of CD23 surface expression appears to be integral with the complex IgE system, which involves interactions of cells, cytokines, antibodies and regulatory factors. CD23 has been described as a membrane bound cytokine, in that the soluble cleavage products of CD23 are themselves able to act as cytokines in vitro.