C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf) antibody

Antigen: C-Fos Induced Growth Factor (Vascular Endothelial Growth Factor D) (Figf)

Synonyms: VEGFD, VEGF-D, FIGF, vegfd, vegf-d, Vegfd, AI325264, Vegf-d

Clonality: Monoclonal (28AT743-288-48)

Host: Mouse

Reactivity: Human

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Certificates: ISO 9001:2008

Catalog no.: ABIN387760

Additional Information

Alternative name: VEGF4

Gene ID: 2277

UniProt: O43915

Immunogen: This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides corresponding to N-terminal, central, and C-terminal sequences of human VEGF4.

Isotype: IgG1

Clone: 28AT743-288-48

Description: Other names: Vascular Endothelial Growth Factor D, c-fos-induced growth factor, FIGF, VEGFD, VEGF-D, VEGF4

Characteristics: Purified Mouse Monoclonal Antibody (Mab)

Specificity: This monoclonal antibody is generated from mice immunized with three KLH conjugated synthetic peptides corresponding to N-terminal, central, and C-terminal sequences of human VEGF4.

Molecular Weight: 40444 DA

Comments:

Background: The protein encoded by this gene is a member of the platelet-derived growth factor/vascular endothelial growth factor (PDGF/VEGF) family and is active in angiogenesis, lymphangiogenesis, and endothelial cell growth. This secreted protein undergoes a complex proteolytic maturation, generating multiple processed forms which bind and activate VEGFR-2 and VEGFR-3 receptors. This protein is structurally and functionally similar to vascular endothelial growth factor C.

Application Details

Application Notes: ELISA~~1:1,000 Western blotting~~1:100~500

Concentration: 0.25 mg/ml

Purification: Purified

Buffer: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles

Research Area: Cell Signaling, Cell Structure, Cancer, Cell Cycle

Restrictions: For Research Use only

Images

The anti-VEGF4 Mab (Cat. #ABIN387760) is used in Western blot to detect VEGF4 in HDMEC cell lysate.

Publications

Product: Becker, Pavlakovic, Ludewig et al.: "Neuroblastoma progression correlates with downregulation of the lymphangiogenesis inhibitor sVEGFR-2." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 5, pp. 1431-41, 2010 (PubMed).

Davila, Froeling, Tan et al.: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, 2010 (PubMed).

Romero, Velez Edwards, Kusanovic et al.: "Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes." in: American journal of obstetrics and gynecology, Vol. 202, Issue 5, pp. 431.e1-34, 2010 (PubMed).

Deguchi, Ichikawa, Soga et al.: "Clinical significance of vascular endothelial growth factors C and D and chemokine receptor CCR7 in gastric cancer." in: Anticancer research, Vol. 30, Issue 6, pp. 2361-6, 2010 (PubMed).

Romero, Friel, Velez Edwards et al.: "A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM)." in: American journal of obstetrics and gynecology, Vol. 203, Issue 4, pp. 361.e1-361.e30, 2010 (PubMed).