Lysine (K)-Specific Demethylase 2A (KDM2A) (AA 500-527), (Center) antibody

Details for Product No. ABIN387896
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Antigen
Synonyms CXXC8, FBL11, FBL7, FBXL11, JHDM1A, LILINA, 100043628, 5530401A10Rik, AA589516, AW536790, Cxxc8, Fbl11, Fbl7, Fbxl11, Gm4560, Jhdm1, Jhdm1a, lalina
Epitope
AA 500-527, Center
(5), (5), (2), (2)
Reactivity
Human
(36), (13), (13), (13), (12), (1), (1)
Host
Rabbit
(32), (3), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (IHC), Western Blotting (WB)
(26), (15), (10), (8), (6), (2), (2), (2), (1)
Pubmed 2 references available
Catalog no. ABIN387896
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Immunogen This JHDM1a/FBXL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 500-527 AA from the Central region of human JHDM1a/FBXL11.
Clone RB14392
Isotype Ig
Specificity This JHDM1a/FBXL11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 506~536 amino acids from the Center of human JHDM1a/FBXL11.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name JHDM1a/FBXL11
Background JHDM1a/FBXL11 is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains at least 6 highly degenerated leucine-rich repeats.
Synonyms: JmjC domain-containing histone demethylation protein 1A, [Histone-H3]-lysine-36 demethylase 1A, F-box/LRR-repeat protein 11, F-box and leucine-rich repeat protein 11, F-box protein FBL7, F-box protein Lilina, CXXC-type zinc finger protein 8, FBXL11
Molecular Weight 132793 DA
Gene ID 22992
UniProt Q9Y2K7
Research Area Signaling, Protein Modifications, Cell Structure
Application Notes IHC = 1:10-50, WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Lysine (K)-Specific Demethylase 2A (KDM2A) (AA 500-527), (Center) antibody Formalin-fixed and paraffin-embedded human testis tissue reacted with JHDM1a/FBXL11 antibody (Center) (ABIN387896), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-Lysine (K)-Specific Demethylase 2A (KDM2A) (AA 500-527), (Center) antibody (2) Western blot analysis of JHDM1a/FBXL11 (arrow) using rabbit polyclonal JHDM1a/FBXL11 Antibody (Center)(ABIN387896).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the JHDM1a/FBXL11 gene (Lane 2) (Origene Technologies).
anti-Lysine (K)-Specific Demethylase 2A (KDM2A) (AA 500-527), (Center) antibody (3) JHDM1a/FBXL11 Antibody (Center) (ABIN387896) western blot analysis in Jurkat cell line lysates (35 µg/lane).This demonstrates the JHDM1a/FBXL11 antibody detected the JHDM1a/FBXL11 protein (arrow).
Background publications Andersen, Lam, Leung et al.: "Nucleolar proteome dynamics." in: Nature, Vol. 433, Issue 7021, pp. 77-83, 2005 (PubMed).

Tsukada, Fang, Erdjument-Bromage et al.: "Histone demethylation by a family of JmjC domain-containing proteins." in: Nature, Vol. 439, Issue 7078, pp. 811-6, 2006 (PubMed).

Hosts (32), (3), (2)
Reactivities (36), (13), (13), (13), (12), (1), (1)
Applications (26), (15), (10), (8), (6), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (5), (5), (2), (2)
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