HAT1 antibody (N-Term)

Catalog No. ABIN387931

This Rabbit Polyclonal antibody specifically detects HAT1 in WB. It exhibits reactivity toward Human.

Quick Overview for HAT1 antibody (N-Term) (ABIN387931)

Target: HAT1 (Histone Acetyltransferase 1 (HAT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HAT1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB5768

Product Details anti-HAT1 Antibody

Binding Specificity: AA 27-58, N-Term

Predicted Reactivity: M, Rat

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This KAT1 (HAT1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 27-58 amino acids from the N-terminal region of human KAT1 (HAT1).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for HAT1

Target: HAT1 (Histone Acetyltransferase 1 (HAT1))

Alternative Name: KAT1 (HAT1)

Background: Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46. The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. HAT1 may play a role in telomeric silencing.

Molecular Weight: 49513

Gene ID: 8520

NCBI Accession: NP_003633

UniProt: O14929