SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (C-Term), (AA 49-81) antibody

Details for Product No. ABIN388034
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Antigen
Synonyms SUMO2
Epitope
C-Term, AA 49-81
(10), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(39), (28), (24), (12), (12)
Host
Rabbit
(36), (2)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(29), (22), (10), (9), (7), (3), (2)
Pubmed 2 references available
Catalog no. ABIN388034
Quantity 400 µL
Price
238.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
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Immunogen This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-81 AA from the C-terminal region of human SUMO2/3.
Clone RB00635
Isotype Ig
Specificity This SUMO2/3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58~88 amino acids within C-terminal region of human SUMO2/3.
Predicted Reactivity Cow (Bovine),Chicken,Hamster,Pig (Porcine),Monkey,Rat (Rattus),Xenopus laevis,Zebrafish
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name SUMO2/3
Background SUMO2 and SUMO3 are members of the SUMO (small ubiquitin-like modifier) protein family. This protein family functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. In vertebrates, three members of the SUMO family have been described, SUMO 1 and the functionally distinct homologues SUMO 2 and SUMO 3. SUMO modification sites present in the N terminal regions of SUMO 2 and SUMO 3 are utilized by SAE1/SAE2 (SUMO E1) and Ubc9 (SUMO E2) to form polymeric chains of SUMO 2 and SUMO 3 on protein substrates, a property not shared by SUMO 1.
Synonyms: Small ubiquitin-like modifier, Ubiquitin-like protein SMT3B, Sentrin 2, HSMT3
Molecular Weight 11637 DA
Gene ID 6612
UniProt P55854
Research Area Apoptosis/Necrosis, Translation Factors, Protein Modifications, Transcription Factors, Signaling, Cell Structure
Application Notes WB = 1:1000, IHC = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (C-Term), (AA 49-81) antibody The anti-SUMO2/3 C-term Pab (ABIN388034) is used in Western blot to detect SUMO2/3 in HeLa cell lysate.
anti-SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (C-Term), (AA 49-81) antibody (2) COS-7 cells were transfected for 24 hrs with a plasmid expressing DYKDDDDK-ERM (left panels) or DYKDDDDK-ERM KR12345 (right panels). Untreated (-) and H2O2-treated (+) cells were collected for immunoblot analysis. Top panels: cell lysates probed by western blot (WB) with an anti-ERM antibody. Center panels: cell lysates immunoprecipitated (IP) with an anti-DYKDDDDK antibody followed by WB with ABIN388027 SUMO-1 antibody. Bottom panels: cell lysates immunoprecipitated with an anti-DYKDDDDK antibody followed by WB with ABIN388034 SUMO-2/3 antibody. (*) represents immunoprecipitated ERM-like forms recognized by anti-SUMO antibodies.
anti-SMT3 Suppressor of Mif Two 3 Homolog 2/3 (SUMO2/3) (C-Term), (AA 49-81) antibody (3) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma
Background publications Lapenta, Chiurazzi, van der Spek et al.: "SMT3A, a human homologue of the S. cerevisiae SMT3 gene, maps to chromosome 21qter and defines a novel gene family." in: Genomics, Vol. 40, Issue 2, pp. 362-6, 1997 (PubMed).

Strausberg, Feingold, Grouse et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Hosts (36), (2)
Reactivities (39), (28), (24), (12), (12)
Applications (29), (22), (10), (9), (7), (3), (2)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (4), (4), (4), (2), (2), (2), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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