|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Bone Morphogenetic Protein 6 (BMP6) (N-Term) antibody
|Synonyms||VGR, VGR1, Vgr1, D13Wsu115e, BMP6, zgc:113595, vgr, vgr1, vgr-1, MGC115308|
Alternatives Western Blotting (WB), ELISA
|4 references available|
|Quantity||400 µL (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33~62 amino acids from the N-terminal region of human Bmp6.|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This Bmp6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33~62 amino acids from the N-terminal region of human Bmp6.|
|Molecular Weight||57225 DA|
Background: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, Bmp6 has a proposed role in early development. In addition, the fact that BMP6 is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry ~~ 1:10~50|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Cell Signaling, Cell Cycle, Cell Structure|
|Restrictions||For Research Use only|
Olavesen, Bentley, Mason et al.: "Fine mapping of 39 ESTs on human chromosome 6p23-p25." in: Genomics, Vol. 46, Issue 2, pp. 303-6, 1998 (PubMed).
Tamada, Kitazawa, Gohji et al.: "Molecular cloning and analysis of the 5'-flanking region of the human bone morphogenetic protein-6 (BMP-6)." in: Biochimica et biophysica acta, Vol. 1395, Issue 3, pp. 247-51, 1998 (PubMed).
Bobacz, Gruber, Soleiman et al.: "Expression of bone morphogenetic protein 6 in healthy and osteoarthritic human articular chondrocytes and stimulation of matrix synthesis in vitro." in: Arthritis and rheumatism, Vol. 48, Issue 9, pp. 2501-8, 2003 (PubMed).
Lories, Derese, Ceuppens et al.: "Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis." in: Arthritis and rheumatism, Vol. 48, Issue 10, pp. 2807-18, 2003 (PubMed).
|Hosts||Rabbit (46), Mouse (6), Goat (1), Sheep (1)|
|Reactivities||Human (46), Rat (Rattus) (26), Mouse (Murine) (25), Pig (Porcine) (20), Cow (Bovine) (19), Dog (Canine) (19), Horse (Equine) (19), Sheep (Ovine) (19)|
|Applications||Western Blotting (WB) (31), ELISA (16), Flow Cytometry (FACS) (15), Immunohistochemistry (IHC) (9), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (9), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunofluorescence (IF) (2), Immunohistochemistry (Fixed) (IHC (fx)) (2), Immunocytochemistry (ICC) (1), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1), Neutralization (Neut) (1)|
|Conjugates||Biotin (6), FITC (3), HRP (2), Alexa Flour 488 (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), Gold (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||N-Term (4), AA 40-55 (2), Internal Region (1)|