URI1 antibody (C-Term)

Catalog No. ABIN388684

This Rabbit Polyclonal antibody specifically detects URI1 in WB. It exhibits reactivity toward Human.

Quick Overview for URI1 antibody (C-Term) (ABIN388684)

Target: URI1 (URI1, Prefoldin-Like Chaperone (URI1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This URI1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB9809

Product Details anti-URI1 Antibody

Binding Specificity: AA 347-376, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This RMP (URI) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-376 amino acids from the C-terminal region of human RMP (URI).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for URI1

Target: URI1 (URI1, Prefoldin-Like Chaperone (URI1))

Alternative Name: RMP (URI)

Background: The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Molecular Weight: 59832

Gene ID: 8725

NCBI Accession: NP_001239570, NP_003787

UniProt: O94763