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Details for Product No. ABIN388782

tau (C-Term), (AA 677-707) antibody

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Antigen
Epitope
»Alternatives C-Term, AA 677-707
Reactivity
»Alternatives Human
Host
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Pubmed 4 references available
Catalog no. ABIN388782
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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Availability Will be delivered in 2 to 3 Business Days
Immunogen This TAU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 677-707 AA from the C-terminal region of human TAU.
Clone RB2883
Isotype Ig
Specificity This TAU antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 685~714 amino acids from the C-terminal region of human TAU.
Predicted Reactivity Cow (Bovine),Mouse (Murine),Rat (Rattus)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background The microtubule-associated protein tau (MAPT) gene transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Synonyms: Microtubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
Molecular Weight 78746 DA
Gene ID 4137
UniProt P10636
Research Area Stem Cells, Cell Structure, Neurology
Application Notes Recommend dilutions: WB : 1:1000,IHC : 1:50-100,IF : 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Kraemer, Zhang, Leverenz et al.: "Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 9980-5, 2003 (PubMed).

Gamblin, Chen, Zambrano et al.: "Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer's disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 17, pp. 10032-7, 2003 (PubMed).

Horiguchi, Uryu, Giasson et al.: "Nitration of tau protein is linked to neurodegeneration in tauopathies." in: The American journal of pathology, Vol. 163, Issue 3, pp. 1021-31, 2003 (PubMed).

Yoshiyama, Zhang, Bruce et al.: "Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 23, Issue 33, pp. 10662-71, 2003 (PubMed).

Alternatives for antigen "tau", type "Antibodies"
Hosts (294), (28), (5), (1)
Reactivities (316), (253), (244), (15), (3), (2), (2), (2), (1), (1), (1), (1)
Applications (286), (161), (69), (19), (13), (13), (13), (13), (12), (9), (9), (7), (1), (1), (1), (1)
Conjugates (2), (1), (1), (1)
Epitopes (24), (16), (14), (13), (12), (12), (12), (11), (10), (10), (10), (9), (9), (8), (5), (4), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
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