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LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 238-270)

Details for Product anti-LGR5 Antibody No. ABIN389215, Supplier: Log in to see
Antigen
  • lgr5-a
  • lgr5a
  • FEX
  • Gpr49
  • GPR49
  • GPR67
  • GRP49
  • HG38
Epitope
AA 238-270, N-Term
21
9
8
5
5
5
5
4
4
4
3
3
2
2
2
2
2
2
2
1
1
1
1
1
Reactivity
Human
115
31
6
Host
Rabbit
70
46
2
Clonality (Clone)
Polyclonal ()
Conjugate
This LGR5 antibody is un-conjugated
2
1
1
1
1
1
Application
Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
74
50
35
29
26
17
17
3
2
2
2
2
1
1
Supplier
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Immunogen This LGR5/GPR49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 238-270 AA from the N-terminal region of human LGR5/GPR49.
Clone RB14764
Isotype Ig
Specificity This LGR5/GPR49 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247~277 amino acids from the N-terminal region of human LGR5.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name LGR5/GPR49 (LGR5 Antibody Abstract)
Background LGR5/GPR49 is an orphan receptor. It may be an important receptor for signals controlling growth and differentiation of specific embryonic tissues.
Synonyms: Leucine-rich repeat-containing G-protein coupled receptor 5 [Precursor], Orphan G-protein coupled receptor HG38, G-protein coupled receptor 49, G-protein coupled receptor 67, LGR5, GPR49, GPR67
Molecular Weight 99867 Da
Gene ID 8549
UniProt O75473
Research Area Cell Signaling, Stem Cells, Cell Structure
Pathways
Application Notes WB = 1:1000, IHC (p) = 1:10-50, FACS = 1:10-50, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 238-270) (ABIN389215) LGR5/GPR49 Antibody (N-term) (ABIN389215) western blot analysis in HepG2 cell line ly...
Immunohistochemistry (IHC) image for anti-LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 238-270) (ABIN389215) Formalin-fixed and paraffin-embedded human brain tissue reacted with LGR5/GPR49 antib...
Flow Cytometry (FACS) image for anti-LGR5 antibody (Leucine-Rich Repeat Containing G Protein-Coupled Receptor 5) (AA 238-270) (ABIN389215) Flow cytometric analysis of HepG2 cells using LGR5/GPR49 Antibody (N-term) (bottom hi...
Product cited in: Jardé, Kass, Staples et al.: "ERBB3 Positively Correlates with Intestinal Stem Cell Markers but Marks a Distinct Non Proliferative Cell Population in Colorectal Cancer." in: PLoS ONE, Vol. 10, Issue 9, pp. e0138336, 2015 (PubMed).

Fender, Nutter, Bertrand et al.: "Notch-1 Promotes Stemness and Epithelial to Mesenchymal Transition in Colorectal Cancer." in: Journal of cellular biochemistry, 2015 (PubMed).

Kanwar, Yu, Nautiyal et al.: "The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres." in: Molecular cancer, Vol. 9, pp. 212, 2010 (PubMed).

Background publications Barker, van Es, Kuipers et al.: "Identification of stem cells in small intestine and colon by marker gene Lgr5." in: Nature, Vol. 449, Issue 7165, pp. 1003-7, 2007 (PubMed).