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Prefoldin Subunit 6 (PFDN6) (AA 6-34), (N-Term) antibody

Details for Product No. ABIN389346, Supplier: Log in to see
Antigen
  • 23.m05913
  • H-2Ke2
  • H2-KE2
  • h2-ke2
  • HKE2
  • hke2
  • KE-2
  • Ke-2
  • ke-2
  • Ke2
  • PFD6
  • pfd6
  • pfdn6
  • Pfdn6
  • pfdn6a
  • pfdn6b
  • zgc:66282
Epitope
AA 6-34, N-Term
11
3
2
2
1
Reactivity
Human
20
5
5
3
1
1
1
Host
Rabbit
16
4
Clonality (Clone)
Polyclonal ()
Application
Western Blotting (WB)
17
6
4
4
3
1
1
1
Supplier
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Immunogen This PFDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 AA from the N-terminal region of human PFDN6.
Clone RB17559
Isotype Ig
Specificity This PFDN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 13~42 amino acids from the C-terminal region of human PFDN6.
Predicted Reactivity Cow (Bovine),Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name PFDN6 (PFDN6 Antibody Abstract)
Background PFDN6 binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. This protein also binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Synonyms: Prefoldin subunit 6, Protein Ke2, PFDN6, HKE2, PFD6
Molecular Weight 14583 DA
Gene ID 10471
UniProt O15212
Research Area Stem Cells
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-Prefoldin Subunit 6 (PFDN6) (AA 6-34), (N-Term) antibody (ABIN389346) Western blot analysis of anti-PFDN6 Antibody (N-term) (ABIN389346) in CEM cell line l...
Product cited in: Tashiro, Zako, Muto, Itoo, Sörgjerd, Terada, Abe, Miyazawa, Kitamura, Kitaura, Kubota, Maeda, Momoi, Iguchi-Ariga, Kinjo, Ariga: "Prefoldin protects neuronal cells from polyglutamine toxicity by preventing aggregation formation." in: The Journal of biological chemistry, Vol. 288, Issue 27, pp. 19958-72, 2013 (PubMed).

Abe, Takahashi-Niki, Takekoshi, Shimizu, Kitaura, Maita, Iguchi-Ariga, Ariga: "Prefoldin plays a role as a clearance factor in preventing proteasome inhibitor-induced protein aggregation." in: The Journal of biological chemistry, Vol. 288, Issue 39, pp. 27764-76, 2013 (PubMed).

Miyazawa, Tashiro, Kitaura, Maita, Suto, Iguchi-Ariga, Ariga: "Prefoldin subunits are protected from ubiquitin-proteasome system-mediated degradation by forming complex with other constituent subunits." in: The Journal of biological chemistry, Vol. 286, Issue 22, pp. 19191-203, 2011 (PubMed).

Background publications Vainberg, Lewis, Rommelaere, Ampe, Vandekerckhove, Klein, Cowan: "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin." in: Cell, Vol. 93, Issue 5, pp. 863-73, 1998 (PubMed).