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ABL2 (Center) antibody

Details for Product No. ABIN389506, Supplier: Log in to see
Antigen
  • ABLL
  • ARG
  • Abll
  • Arg
  • AA536808
Epitope
Center
20
17
16
11
8
7
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
118
29
20
Host
Rabbit
82
36
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
7
7
7
6
6
6
1
1
1
1
1
1
1
1
1
Application
Dot Blot (DB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
99
78
25
23
11
9
7
5
5
2
1
1
Supplier
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Immunogen This ABL Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y412 of human ABL.
Clone RB7532
Isotype Ig
Specificity This Phospho-ABL-Y412 Antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the central region of human ABL.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein G column, followed by dialysis against PBS.
Background ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells.
Synonyms: Tyrosine-protein kinase ABL2, Abelson murine leukemia viral oncogene homolog 2, Tyrosine kinase ARG, ABL2, ABLL, ARG,
Molecular Weight 128343 DA
Gene ID 27
UniProt P42684
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure
Application Notes WB = 1:1000, DB = 1:500, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 0.34 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ABL2 (Center) antibody (ABIN389506) Western blot analysis of anti-ABL2 Pab (ABIN389506) in A2058 cell line lysate (35 µg/...
Dot Blot (DB) image for anti-ABL2 (Center) antibody (ABIN389506) Dot blot analysis of ABL-Y412 Phospho-specific Pab (ABIN389506) on nitrocellulose mem...
Immunohistochemistry (IHC) image for anti-ABL2 (Center) antibody (ABIN389506) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Background publications Cao, Leng, Liu et al.: "Catalase is regulated by ubiquitination and proteosomal degradation. Role of the c-Abl and Arg tyrosine kinases." in: Biochemistry, Vol. 42, Issue 35, pp. 10348-53, 2003 (PubMed).

Cao, Leng, Kufe: "Catalase activity is regulated by c-Abl and Arg in the oxidative stress response." in: The Journal of biological chemistry, Vol. 278, Issue 32, pp. 29667-75, 2003 (PubMed).

Kruh, King, Kraus et al.: "A novel human gene closely related to the abl proto-oncogene." in: Science (New York, N.Y.), Vol. 234, Issue 4783, pp. 1545-8, 1987 (PubMed).

Kruh, Perego, Miki et al.: "The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 15, pp. 5802-6, 1990 (PubMed).