CREB1 antibody (pSer133)

Catalog No. ABIN389547

Cited in 1 publication. The Rabbit Polyclonal anti-CREB1 antibody (Clone RB05198) (ABIN389547) specifically detects CREB1 in WB, IF and IHC (p). The antibody is reactive with Human samples.

Quick Overview for CREB1 antibody (pSer133) (ABIN389547)

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CREB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB05198

Product Details anti-CREB1 Antibody

Binding Specificity: pSer133

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CREB Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S133 of human CREB.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:500. WB: 1:500. WB: 1:500. IHC-P-Leica: 1:500. IHC-P-Leica: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CREB1 antibody (ABIN389547)

Abe, Matsui, Watanabe: "Transgenic songbirds with suppressed or enhanced activity of CREB transcription factor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 24, pp. 7599-604, (2015) (PubMed).

Target Details for CREB1

Target: CREB1 (cAMP Responsive Element Binding Protein 1 (CREB1))

Alternative Name: CREB

Background: CREB is a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, (CRE), a sequence present in many viral and cellular promoters. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway.

Molecular Weight: 35136

Gene ID: 1385

NCBI Accession: NP_004370, NP_604391

UniProt: P16220

Pathways: TLR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Activation of Innate immune Response, Myometrial Relaxation and Contraction, Regulation of Cell Size, Toll-Like Receptors Cascades, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Positive Regulation of fat Cell Differentiation