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Details for Product No. ABIN389996

Cyclin-Dependent Kinase 2 (CDK2) (pThr14) antibody

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Synonyms p33(CDK2), A630093N05Rik, zgc:56598, zgc:77684, wu:fa10c02, eg1, MGC84068, cinp, CINP
»Alternatives pThr14
»Alternatives Human
»Alternatives Rabbit
Clonality (Clone) Polyclonal ()
»Alternatives Un-conjugated
»Alternatives Dot Blot (DB)
Pubmed 4 references available
Catalog no. ABIN389996
Quantity 400 µL
291.50 $   Plus shipping costs $45.00
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Immunogen This CDK2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T14 of human CDK2.
Clone RB7700
Isotype Ig
Specificity This Phospho-CDK2-pT14 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T14 of human CDK2.
Predicted Reactivity Cow (Bovine),Hamster,Mouse (Murine),Rat (Rattus),Xenopus laevis
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Cdk2
Background CDK2 is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation.
Synonyms: Cell division protein kinase 2, p33 protein kinase
Molecular Weight 33930 DA
Gene ID 1017
UniProt P24941
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Transcription Factors, Signaling, Cell Structure
Application Notes Recommend dilutions: DB : 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.5 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Background publications Gu, Rosenblatt, Morgan: "Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15." in: The EMBO journal, Vol. 11, Issue 11, pp. 3995-4005, 1992 (PubMed).

Tsai, Harlow, Meyerson: "Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated p33 kinase." in: Nature, Vol. 353, Issue 6340, pp. 174-7, 1991 (PubMed).

Elledge, Spottswood: "A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1." in: The EMBO journal, Vol. 10, Issue 9, pp. 2653-9, 1991 (PubMed).

Ninomiya-Tsuji, Nomoto, Yasuda et al.: "Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 88, Issue 20, pp. 9006-10, 1991 (PubMed).

Alternatives for antigen "Cyclin-Dependent Kinase 2 (CDK2)", type "Antibodies"
Hosts (155), (45)
Reactivities (187), (90), (82), (26), (15), (12), (12), (5), (3), (2), (2), (1)
Applications (170), (75), (69), (39), (37), (29), (20), (16), (13), (6), (4), (4), (2), (1), (1), (1), (1), (1), (1)
Conjugates (7), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (35), (27), (16), (5), (4), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1)