SRY (Sex Determining Region Y)-Box 2 (SOX2) (pSer83) antibody

Details for Product No. ABIN390034
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Antigen
Synonyms Qscn6, Qsox, Sox-2, rSOx, ANOP3, MCOPS3, RGD1565646, SRY-box2, Xsox-2, anop3, mcops3, sox-2, lcc, ysb, cb236, wu:fb83g04, wu:fc14d07, zgc:65860, zgc:77389
Epitope
pSer83
(36), (16), (14), (11), (10), (8), (8), (7), (7), (7), (6), (4), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(240), (60), (40), (9), (8), (8), (5), (4), (4), (4), (3), (3), (2), (1), (1), (1), (1)
Host
Rabbit
(198), (49), (6)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(14), (13), (12), (12), (10), (10), (1), (1), (1), (1), (1)
Application
Dot Blot (DB)
(180), (102), (50), (45), (42), (38), (33), (28), (18), (10), (7), (5), (5), (3), (1), (1), (1)
Pubmed 5 references available
Quantity 400 μL
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Immunogen This SOX2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S83 of human SOX2.
Clone RB18923
Isotype Ig
Specificity This Phospho-SOX2-S83 antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide between 72~101 amino acids surrounding S83 of human SOX2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is purified through a protein A column, followed by peptide affinity purification.
Alternative Name Sox2 (SOX2 Antibody Abstract)
Background SOX2 is a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. This protein may act as a transcriptional activator after forming a protein complex with other proteins. Mutations in the SOX2 gene have been associated with bilateral anophthalmia, a severe form of structural eye malformation.
Synonyms: Transcription factor SOX-2
Molecular Weight 34310 DA
Gene ID 6657
UniProt P48431
Research Area Stem Cells, Phospho-specific antibodies, Transcription Factors, Signaling
Application Notes DB = 1:500
Restrictions For Research Use only
Format Liquid
Concentration 0.395 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) (pSer83) antibody Dot blot analysis of anti-Phospho-SOX2-S83 Antibody (ABIN390034) on nitrocellulose me...
Background publications Reményi, Lins, Nissen et al.: "Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers." in: Genes & development, Vol. 17, Issue 16, pp. 2048-59, 2003 (PubMed).

Wiebe, Nowling, Rizzino: "Identification of novel domains within Sox-2 and Sox-11 involved in autoinhibition of DNA binding and partnership specificity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 17901-11, 2003 (PubMed).

Fantes, Ragge, Lynch et al.: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Schepers, Teasdale, Koopman: "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families." in: Developmental cell, Vol. 3, Issue 2, pp. 167-70, 2002 (PubMed).

Kamachi, Uchikawa, Kondoh: "Pairing SOX off: with partners in the regulation of embryonic development." in: Trends in genetics : TIG, Vol. 16, Issue 4, pp. 182-7, 2000 (PubMed).

Validation Images
Catalog No. ABIN390034
291.50 $
Plus shipping costs $45.00
Quantity
Price
400 μL
291.50 $

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