XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 1-30)

Details for Product anti-XIAP Antibody No. ABIN390070, Supplier: Log in to see
Antigen
  • BIRC4
  • api3
  • birc4
  • ilp1
  • miha
  • xlp2
  • xxiap
  • API3
  • IAP-3
  • ILP1
  • MIHA
  • XLP2
  • hIAP-3
  • hIAP3
  • 1110015C02Rik
  • Aipa
  • Api3
  • Birc4
  • IAP3
  • ILP-1
  • mXIAP
  • riap3
  • X-linked inhibitor of apoptosis
  • XIAP
  • xiap
  • Xiap
Alternatives
anti-Mouse (Murine) XIAP antibody for ELISA
Epitope
AA 1-30, N-Term
20
18
15
9
8
8
8
6
5
5
4
4
4
4
3
2
2
2
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
184
93
62
7
5
5
2
Host
Rabbit
158
26
1
Clonality (Clone)
Polyclonal ()
Conjugate
This XIAP antibody is un-conjugated
6
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
161
71
52
45
31
23
13
13
9
9
3
3
2
1
1
Options
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Immunogen This XIAP (BIRC4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 AA from the N-terminal region of human XIAP (BIRC4).
Clone RB01793
Isotype Ig
Specificity This XIAP (BIRC4) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 5~34 amino acids from the N-terminal region of human BIRC4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name XIAP (BIRC4) (XIAP Antibody Abstract)
Background BIRC4 is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to API1, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7.
Synonyms: Baculoviral IAP repeat-containing protein 4, Inhibitor of apoptosis protein 3, X-linked inhibitor of apoptosis protein, X-linked IAP, IAP-like protein, HILP, API3, IAP3, XIAP
Molecular Weight 56684 DA
Gene ID 331
UniProt P98170
Research Area Apoptosis/Necrosis, Cancer, Cell Structure
Pathways Apoptosis, Caspase Cascade in Apoptosis, Transition Metal Ion Homeostasis
Application Notes WB = 1:1000, IHC (p) = 1:50-100
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 1-30) (ABIN390070) The anti-BIRC4 N-term Pab (ABIN390070) is used in Western blot to detect BIRC4 in mou...
Western Blotting (WB) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 1-30) (ABIN390070) Western blot analysis of anti-BIRC4 Antibody (N-term) (ABIN390070) in Ramos cell line...
Immunohistochemistry (IHC) image for anti-XIAP antibody (X-Linked Inhibitor of Apoptosis) (AA 1-30) (ABIN390070) Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with BIRC4 ...
Background publications Srinivasula, Gupta, Datta, Zhang, Hegde, Cheong, Fernandes-Alnemri, Alnemri: "Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2." in: The Journal of biological chemistry, Vol. 278, Issue 34, pp. 31469-72, 2003 (PubMed).

Miranda, Dyer, Grandis, Johnson: "Differential activation of apoptosis regulatory pathways during monocytic vs granulocytic differentiation: a requirement for Bcl-X(L)and XIAP in the prolonged survival of monocytic cells." in: Leukemia, Vol. 17, Issue 2, pp. 390-400, 2003 (PubMed).