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MAFK (AA 57-85), (C-Term) antibody

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Synonyms NFE2U, P18, AW061068, NF-E2, Nfe2u
AA 57-85, C-Term
(16), (6), (1)
(29), (6), (3), (2), (2), (2), (2), (1), (1)
(23), (7)
Clonality (Clone)
Polyclonal ()
(2), (2), (2), (2), (2), (2)
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(28), (17), (13), (3), (2), (2)
Pubmed 5 references available
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Quantity 400 μL
Shipping to United States ( )
Availability Will be delivered in 2 to 4 Business Days
Immunogen This SEPT9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-85 AA from the C-terminal region of human SEPT9.
Clone RB1931
Isotype Ig
Specificity This SEPT9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539~568 amino acids from the C-terminal region of human SEPT9.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Background The maf oncogene was identified by structural analysis of the AS42 avian transforming retrovirus genome. The Maf family is divided into two subclasses, large Mafs (vMaf, cMaf, MafB and Nrl) and small Mafs (MafF, MafK, and MafG). Both subclasses contain leucinezipper motifs, which allow homodimerization as well as heterodimerization with a variety of other bZip transcription factors. Large Mafs also contain an acidic transactivation domain absent in the small Maf proteins. Although they do not possess inherent transactivation activity, small Maf proteins can act as positive regulators of transcription by targeting transcriptionally active dimerization partners to specific DNA regulatory elements. Conversely, small Mafs can act also as negative regulators of transcription by recruiting transcriptional repressors or by forming homodimers that can replace active dimers. Human MafF was isolated in a yeast one-hybrid system from a human myometrium cDNA library. Human MAFF encodes a 164 amino acids proten. Like other small MAFF proteins, it contains an extended leucine zipper structure and lacks an N-terminal transactivating domain. The three small Maf proteins have been implicated in a number of physiological processes, including development, differentiation, haematopoiesis and stress response. Interestingly, these three proteins regulate the stress response via different mechanisms.
Synonyms: MAFK
Molecular Weight 63633 DA
Gene ID 7975
NCBI Accession NP_002351
Research Area Cancer, Cell Cycle, Cell Structure
Application Notes IHC (p) = 1:50-100, WB = 1:1000, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-MAFK (AA 57-85), (C-Term) antibody (ABIN390155) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-MAFK (AA 57-85), (C-Term) antibody (ABIN390155) The anti-MAFK Pab (ABIN390155) is used in Western blot to detect MAFK in Jurkat cell ...
Product cited in: Amir, Golan, Mabjeesh: "Targeted knockdown of SEPT9_v1 inhibits tumor growth and angiogenesis of human prostate cancer cells concomitant with disruption of hypoxia-inducible factor-1 pathway." in: Molecular cancer research : MCR, Vol. 8, Issue 5, pp. 643-52, 2010 (PubMed).

Bennett, Romigh, Eng: "Disruption of transforming growth factor-beta signaling by five frequently methylated genes leads to head and neck squamous cell carcinoma pathogenesis." in: Cancer research, Vol. 69, Issue 24, pp. 9301-5, 2009 (PubMed).

Background publications McIlhatton, Burrows, Donaghy et al.: "Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3." in: Oncogene, Vol. 20, Issue 41, pp. 5930-9, 2001 (PubMed).

Russell, McIlhatton, Burrows et al.: "Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors." in: Cancer research, Vol. 60, Issue 17, pp. 4729-34, 2000 (PubMed).

Osaka, Rowley, Zeleznik-Le: "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 11, pp. 6428-33, 1999 (PubMed).

Catalog No. ABIN390155
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