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Amyloid beta (A4) Precursor Protein (APP) (N-Term) antibody

Antigen

Amyloid beta (A4) Precursor Protein (APP)
Synonyms APP, APP-like, APPL, Abeta, BcDNA:GH04413, EG:65F1.5, DmelCG7727, CG7727, AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, CTFgamma, aaa, ad1, pn2, abpp, appi, cvap, abeta, MGC88882, ctfgamma
Binding Site
Alternatives

N-Term
Clonality Polyclonal
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), ELISA
3 references available
Certificates ISO 9001:2008
Catalog no. ABIN390282
Quantity 0.1 mg  (0.25 mg/ml)
Price 280.50 $   Plus shipping costs $45.00
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anti-Amyloid beta (A4) Precursor Protein (APP) (N-Term) antibody

anti-Amyloid beta (A4) Precursor Protein (APP) (N-Term) antibody (2)

anti-Amyloid beta (A4) Precursor Protein (APP) (N-Term) antibody (3)

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name APP
Gene ID 351
UniProt A4_HUMAN
Immunogen This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human APP.
Isotype Ig
Description Other names: Alzheimer's disease amyloid A4 protein homolog , Soluble APP-beta, CTF-alpha, Beta-amyloid protein 42, Beta-APP42, Beta-amyloid protein 40, Beta-APP40, Gamma-CTF(59), Gamma-secretase C-terminal fragment 59), Gamma-CTF(57), (Gamma-secretase C-terminal fra
Characteristics Purified Rabbit Polyclonal Antibody (Pab)
Specificity This APP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human APP.
Molecular Weight 86943 DA
Comments

Background: APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

Application Details
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Application Notes The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:50~100 Immunohistochemistry ~~ 1:10~50 Flow cytometric~~1:10~50
Concentration 0.25 mg/ml
Purification Purified
Buffer Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles
Research Area Apoptosis/Necrosis, Signaling, Protein Modifications, Cell Structure, Transcription Factors, Neurology
Restrictions For Research Use only

Publications
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Product Murakami, Irie, Morimoto et al.: "Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease." in: The Journal of biological chemistry, Vol. 278, Issue 46, pp. 46179-87, 2003 (PubMed).

Kim, Kim, Lee et al.: "Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site." in: Biochemical and biophysical research communications, Vol. 310, Issue 3, pp. 904-9, 2003 (PubMed).

Zhou, Su, Li et al.: "Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho." in: Science (New York, N.Y.), Vol. 302, Issue 5648, pp. 1215-7, 2003 (PubMed).

Alternatives
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Alternatives for antigen "Amyloid beta (A4) Precursor Protein (APP)", type "Antibodies"
Hosts Rabbit (233), Mouse (67), Goat (34), Chicken (3)
Reactivities Human (298), Mouse (Murine) (146), Rat (Rattus) (134), Cow (Bovine) (75), Dog (Canine) (70), Chicken (69), Pig (Porcine) (68), Horse (Equine) (56), Monkey (9), Sheep (Ovine) (5), Rabbit (3), Guinea Pig (2), Xenopus laevis (2), Zebrafish (2), Cat (Feline) (1), Fruit Fly (Drosophila melanogaster) (1), Primate (1)
Applications Western Blotting (WB) (238), ELISA (122), Immunofluorescence (IF) (84), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (75), Immunohistochemistry (IHC) (61), Immunoprecipitation (IP) (23), Flow Cytometry (FACS) (11), Immunohistochemistry (Fixed) (IHC (fx)) (8), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (8), Immunohistochemistry (Frozen Sections) (IHC (fro)) (7), Immunocytochemistry (ICC) (5), Immunoelectron Microscopy (IEM) (2), Dot Blot (Dot) (1), Enzyme Immunoassay (EIA) (1)
Conjugates Alexa Fluor 350 (8), Alexa Fluor 488 (8), Alexa Fluor 555 (8), Alexa Fluor 647 (8), PE,Cy5.5 (8), Biotin (4), FITC (4), HRP (3), Cy3 (2), Cy5 (2), Cy5.5 (2), Cy7 (2), Gold (2), PE (2), PE,Cy3 (2), PE,Cy5 (2), PE,Cy7 (2)
Epitopes N-Term (25), C-Term (21), Transcript Variant 1 (10), pThr668 (10), pThr743 (9), pSer198 (6), pSer730 (6), pTyr757 (5), AA 44-63 (4), AA 737-751 (4), AA 292-312 (3), Internal Region (3), Thr668 (3), AA 18-289 (2), AA 653-662 (2), AA 660-669 (2), AA 681-695 (2), AA 747-761 (2), Frameshift Mutant (2), pTyr756 (2), AA 1-14 (1), AA 1-16 (1), AA 339-348 (1), AA 350-450 (1), AA 36-42 (1), AA 671-685 (1), AA 73-7 (1), C-Term,Asp672 (1), Center (1), Extracellular Domain (1), Frameshift Mutant, AA 339-348 (1), Frameshift Mutant, C-Term (1), KPI Domain (1), N-Term,AA 18-32 (1), OX-2 Domain (1), Precursor, AA 653-662 (1), Precursor, C-Term, AA 737-751 (1), Ser730 (1), Thr743, Thr668 (1), Tyr756 (1), Wild Type (1), pSer129 (1), pSer182 (1), pSer264 (1), pSer347 (1), pSer498,pSer490 (1), pThr743, pThr668 (1)