APP antibody (C-Term)

Catalog No. ABIN3029934

The Rabbit Polyclonal anti-APP antibody (ABIN3029934) specifically detects APP in WB, IF, ICC and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for APP antibody (C-Term) (ABIN3029934)

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This APP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-APP Antibody

Binding Specificity: C-Term

Purpose: Amyloid beta Antibody / APP

Sequence: DAEFRHDSGY EVHHQKLVFF AEDVGSNKGA IIGLMVGGVV IA

Purification: Antigen affinity

Immunogen: An amino acid sequence from the C-terminus of human APP (DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA) was used as the immunogen for this Amyloid beta antibody.

Isotype: IgG

Application Details

Application Notes: The stated application concentrations are suggested starting amounts. Titration of the Amyloid beta antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Amyloid beta antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for APP

Target: APP (Amyloid beta (A4) Precursor Protein (APP))

Alternative Name: Amyloid beta (APP)

Background: Amyloid beta, also called Abeta and APP, denotes peptides that are crucially involved in Alzheimers disease as the main component of the amyloid plaques found in the brains of Alzheimer patients. Several potential activities have been discovered for Amyloid beta, including activation of kinase enzymes, functioning as a transcription factor, and anti-microbial activity (potentially associated with it pro-inflammatory activity). Moreover, monomeric Amyloid beta is indicated to protect neurons by quenching metal-inducible oxygen radical generation and thereby inhibiting neurotoxicity.

UniProt: P05067

Pathways: Caspase Cascade in Apoptosis, EGFR Signaling Pathway, Transition Metal Ion Homeostasis, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, Feeding Behaviour