DIO1 antibody (N-Term)

Catalog No. ABIN390946

This Rabbit Polyclonal antibody specifically detects DIO1 in WB. It exhibits reactivity toward Human.

Quick Overview for DIO1 antibody (N-Term) (ABIN390946)

Target: DIO1 (Deiodinase, Iodothyronine, Type I (DIO1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DIO1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB21147

Product Details anti-DIO1 Antibody

Binding Specificity: AA 30-57, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DIO1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-57 amino acids from the N-terminal region of human DIO1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for DIO1

Target: DIO1 (Deiodinase, Iodothyronine, Type I (DIO1))

Alternative Name: DIO1

Background: DIO1 is a thiol-requiring propylthiouracil-sensitive oxidoreductase. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It also degrades both hormones by inner ring deiodination (IRD).

Molecular Weight: 28924

Gene ID: 1733

NCBI Accession: NP_000783, NP_001034804, NP_001034805, NP_998758

UniProt: P49895

Pathways: Hormone Activity