CAMKII gamma antibody (C-Term)

Catalog No. ABIN391313

There is 1 publication for this product available. The Rabbit Polyclonal anti-CAMKII gamma antibody is suitable to detect CAMKII gamma in samples from Human and Mouse. It has been validated for WB and IHC (p).

Quick Overview for CAMKII gamma antibody (C-Term) (ABIN391313)

Target: CAMKII gamma (CAMK2G) (Calcium/calmodulin-Dependent Protein Kinase II gamma (CAMK2G))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CAMKII gamma antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1246

Product Details anti-CAMKII gamma Antibody

Binding Specificity: AA 309-338, C-Term

Purification: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This CAMK2G (CAMK2 gamma) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-338 amino acids from the C-terminal region of human CAMK2G (CAMK2 gamma).

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. WB: 1:500-1000. WB: 1:500. WB: 1:2000. IHC-P: 1:50~100. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-CAMKII gamma antibody (ABIN391313)

Jiang, Wu, Lu, Zhang, Yu, Gan, Wu, Xu, Zheng, Zhang, Xu, Ma, Gan, Huang, Yu, Huang, Xu: "Activation of CaMKIIγ potentiates T-cell acute lymphoblastic leukemia leukemogenesis via phosphorylating FOXO3a." in: Oncotarget, Vol. 8, Issue 43, pp. 75050-75064, (2017) (PubMed).

Target Details for CAMKII gamma

Target: CAMKII gamma (CAMK2G) (Calcium/calmodulin-Dependent Protein Kinase II gamma (CAMK2G))

Alternative Name: CAMK2G (CAMK2 gamma)

Background: CaM-kinase II (CAMK2) is a prominent Ser/Thr protein kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Likely autophosphorylation of Thr-286 allows the kinase to switch from a calmodulin-dependent to a calmodulin-independent state. CAMK2 is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits.

Molecular Weight: 62607

Gene ID: 818

NCBI Accession: NP_001213, NP_751909, NP_751913

UniProt: Q13555

Pathways: WNT Signaling, Interferon-gamma Pathway, Hormone Transport, Myometrial Relaxation and Contraction, Regulation of long-term Neuronal Synaptic Plasticity