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ABCC4 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) (AA 1117-1145)

Details for Product anti-ABCC4 Antibody No. ABIN391639, Supplier: Log in to see
Antigen
  • D630049P08Rik
  • EST170205
  • MOAT-B
  • MOATB
  • Mrp4
  • MRP4
Epitope
AA 1117-1145, C-Term
23
18
13
9
8
5
4
3
2
2
1
1
1
1
Reactivity
Human
112
42
33
1
1
1
1
Host
Rabbit
47
41
25
10
Clonality (Clone)
Polyclonal ()
Conjugate
This ABCC4 antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
98
63
49
25
17
11
10
9
7
4
2
1
Supplier
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Immunogen This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1117-1145 AA from the C-terminal region of human ABCC4.
Clone RB17763
Isotype Ig
Specificity This ABCC4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1124~1153 amino acids from the C-terminal region of human ABCC4.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ABCC4 (ABCC4 Antibody Abstract)
Background ABCC4 is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC proteins are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined, however, this protein may play a role in cellular detoxification as a pump for its substrate, organic anions.
Synonyms: Multi-specific organic anion transporter B, MOAT-B, MRP/cMOAT-related ABC transporter, ATP-binding cassette sub-family C member 4, Multidrug resistance-associated protein 4, ABCC4, MRP4
Molecular Weight 149527 DA
Gene ID 10257
UniProt O15439
Research Area Cell Structure
Application Notes WB = 1:1000
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Western Blotting (WB) image for anti-ABCC4 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 4) (AA 1117-1145) (ABIN391639) Western blot analysis of anti-ABCC4 Antibody (C-term) (ABIN391639) in CEM cell line l...
Background publications Adachi, Sampath, Lan, Sun, Hargrove, Flatley, Tatum, Edwards, Wezeman, Matherly, Drake, Schuetz: "Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38998-9004, 2002 (PubMed).

Lee, Belinsky, Bell, Testa, Kruh: "Isolation of MOAT-B, a widely expressed multidrug resistance-associated protein/canalicular multispecific organic anion transporter-related transporter." in: Cancer research, Vol. 58, Issue 13, pp. 2741-7, 1998 (PubMed).

Kool, de Haas, Scheffer, Scheper, van Eijk, Juijn, Baas, Borst: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).