|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Mitogen-Activated Protein Kinase 7 (MAPK7) (C-Term) antibody
|Synonyms||BMK1, ERK4, ERK5, PRKM7, Erk5-T, ATMPK7, F8D23.5, F8D23_5, MAP kinase 7, MPK7|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|2 references available|
|Quantity||0.1 mg (0.25 mg/ml) (Variants)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This ERK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782~812 amino acids from the C-terminal region of human ERK5.|
|Description||Other names: Extracellular signal-regulated kinase 5, Mitogen-activated protein kinase 7|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This ERK5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 782~812 amino acids from the C-terminal region of human ERK5.|
|Molecular Weight||88636 DA|
Background: MEK5 and ERK5, a member of the MAP kinase subfamily of the Ser/Thr protein kinases, interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. ERK5 is activated by tyrosine and threonine phosphorylation It is expressed in many adult tissues, abundantly in heart, placenta, lung, kidney and skeletal muscle, but is not detectable in liver. The second proline-rich region may interact with actin targeting the kinase to a specific location in the cell. ERK5 is autophosphorylated on threonine and tyrosine residues when the C-terminal part of the kinase, which could have a regulatory role, is absent.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure|
|Restrictions||For Research Use only|
Lee, Ulevitch, Han: "Primary structure of BMK1: a new mammalian map kinase." in: Biochemical and biophysical research communications, Vol. 213, Issue 2, pp. 715-24, 1995 (PubMed).
Zhou, Bao, Dixon: "Components of a new human protein kinase signal transduction pathway." in: The Journal of biological chemistry, Vol. 270, Issue 21, pp. 12665-9, 1995 (PubMed).