|+1 404 474 4654|
|+1 888 205 9894 (TF)|
Cyclin-Dependent Kinase Inhibitor 3 (CDKN3) (C-Term) antibody
|Synonyms||KAP, CDI1, CIP2, KAP1, FLJ25787, MGC70625, CDKN3, MGC133531, 2410006H10Rik|
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|4 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183~212 amino acids from the C-terminal region of human CDKN3.|
|Description||Other names: Cyclin-dependent kinase inhibitor 3, CDK2-associated dual specificity phosphatase, Kinase associated phosphatase, Cyclin-dependent kinase interacting protein 2, Cyclin-dependent kinase interactor 1|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This CDKN3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183~212 amino acids from the C-terminal region of human CDKN3.|
|Molecular Weight||23805 DA|
Background: CDKN3 belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. The gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cancer, Cell Cycle, Cell Structure|
|Restrictions||For Research Use only|
Poon, Hunter: "Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin." in: Science (New York, N.Y.), Vol. 270, Issue 5233, pp. 90-3, 1995 (PubMed).
Hannon, Casso, Beach: "KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1731-5, 1994 (PubMed).
Lee, Reimer, Fang et al.: "Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression." in: Molecular and cellular biology, Vol. 20, Issue 5, pp. 1723-32, 2000 (PubMed).
Yeh, Lu, Chen et al.: "Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma." in: Cancer research, Vol. 60, Issue 17, pp. 4697-700, 2000 (PubMed).
|Hosts||Rabbit (28), Mouse (9)|
|Reactivities||Human (35), Mouse (Murine) (4), Cow (Bovine) (1), Dog (Canine) (1), Pig (Porcine) (1), Rat (Rattus) (1)|
|Applications||Western Blotting (WB) (22), Immunofluorescence (IF) (18), ELISA (7), Flow Cytometry (FACS) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (7), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunohistochemistry (IHC) (2), Immunoelectron Microscopy (IEM) (1), Immunoprecipitation (IP) (1)|
|Conjugates||Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (2), N-Term (2), AA 195-212 (1), pThr595 (1)|