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AXL Receptor tyrosine Kinase (AXL) antibody

Details for Product No. ABIN391878
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Antigen
Synonyms JTK11, UFO, AI323647, Ark, Tyro7, Ufo
Reactivity
Human
(124), (54), (46), (34), (19), (17), (1)
Host
Rabbit
(98), (32), (2), (1), (1)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(5), (5), (5), (5), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)
(98), (62), (41), (28), (28), (16), (12), (7), (5), (4), (2), (1)
Pubmed 4 references available
Quantity 400 µL
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Catalog No. ABIN391878
291.50 $
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Immunogen This AXL antibody is generated from rabbits immunized with a his tag recombinant protein of human AXL.
Clone RB17700
Isotype Ig
Specificity This AXL antibody is generated from rabbits immunized with a his tag recombinant protein of human AXL.
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name AXL
Background AXL, a member of the AXL/UFO subfamily of Tyr protein kinases, may function as a signal transducer between specific cell types of mesodermal origin. This Type I membrane protein has transforming potential in patients with chronic myeloproliferative disorder or chronic myelocytic leukemia. The protein contains 2 putative fibronectin type III domains and 2 putative immunoglobulin-like C2-type domains.
Synonyms: Tyrosine-protein kinase receptor UFO precursor, AXL oncogene
Molecular Weight 97374 DA
Gene ID 558
UniProt P30530
Research Area Phospho-specific antibodies, Protein Modifications, Cell Structure, Cancer
Application Notes WB = 1:1000, IHC = 1:50-100, FACS = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-AXL Receptor tyrosine Kinase (AXL) antibody Western blot analysis of anti-AXL Antibody (ABIN391878) in A375 cell line lysates (35 µg/lane). AXL(arrow) was detected using the purified polyclonal antibody.
anti-AXL Receptor tyrosine Kinase (AXL) antibody (2) Formalin-fixed and paraffin-embedded human colon carcinoma with AXL Antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
anti-AXL Receptor tyrosine Kinase (AXL) antibody (3) Flow cytometric analysis of WiDr cells using AXL Antibody(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Background publications OBryan, Frye, Cogswell et al.: "axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase." in: Molecular and cellular biology, Vol. 11, Issue 10, pp. 5016-31, 1991 (PubMed).

Janssen, Schulz, Steenvoorden et al.: "A novel putative tyrosine kinase receptor with oncogenic potential." in: Oncogene, Vol. 6, Issue 11, pp. 2113-20, 1991 (PubMed).

Partanen, Mäkelä, Alitalo et al.: "Putative tyrosine kinases expressed in K-562 human leukemia cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, Issue 22, pp. 8913-7, 1991 (PubMed).

Lee, Strunk, Spritz: "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes." in: Oncogene, Vol. 8, Issue 12, pp. 3403-10, 1993 (PubMed).

Validation Images
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