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Fibroblast Growth Factor Receptor 2 (FGFR2) (C-Term) antibody
Alternatives Western Blotting (WB), Immunohistochemistry (IHC), ELISA
|5 references available|
|Quantity||0.1 mg (0.25 mg/ml)|
|Price||280.50 $ Plus shipping costs $45.00|
|Availability||Will be delivered in 2 to 3 Business Days|
|Immunogen||This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792~821 amino acids from the C-terminal region of human FGFR2.|
|Description||Other names: fibroblast growth factor receptor 2|
|Characteristics||Purified Rabbit Polyclonal Antibody (Pab)|
|Specificity||This FGFR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 792~821 amino acids from the C-terminal region of human FGFR2.|
|Molecular Weight||92025 DA|
Background: FGFR2 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in the gene are associated with many craniosynostotic syndromes and bone malformations. The genomic organization of the gene encompasses 20 exons. Alternative splicing in multiple exons, including those encoding the Ig-like domains, the transmembrane region and the carboxyl terminus, results in varied isoforms which differ in structure and specificity. Isoform 1 has equal affinity for aFGF and bFGF but does not bind KGF.
|Synonyms||Fgfr2, BEK, JWS, CEK3, CFD1, ECT1, KGFR, TK14, TK25, BFR-1, CD332, K-SAM, FLJ98662, Bek, svs, Fgfr7, Fgfr-2, Fgfr-7, KGFRTr, AU043015, AW556123, MGC102519, wu:fc56c05, FGFR2, cek3, FGF-R, FGFR2IIIb, fgfr72IIIb, FGFR, bek, jws, cfd1, ect1, kgfr, tk14, tk25, bfr-1, cd332, k-sam, xfgfr2, DKFZp469H1521|
|Application Notes||The suggested dilution is: ELISA~~1:1,000 Western blotting~~1:100~500 Immunohistochemistry~~1:50~100|
|Buffer||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles|
|Research Area||Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Structure, Cell Cycle|
|Restrictions||For Research Use only|
Katoh, Katoh: "FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26." in: International journal of oncology, Vol. 22, Issue 5, pp. 1155-9, 2003 (PubMed).
Katoh, Katoh: "Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26." in: International journal of molecular medicine, Vol. 11, Issue 5, pp. 579-83, 2003 (PubMed).
Fomenkov, Huang, Topaloglu et al.: "P63 alpha mutations lead to aberrant splicing of keratinocyte growth factor receptor in the Hay-Wells syndrome." in: The Journal of biological chemistry, Vol. 278, Issue 26, pp. 23906-14, 2003 (PubMed).
Goriely, McVean, Röjmyr et al.: "Evidence for selective advantage of pathogenic FGFR2 mutations in the male germ line." in: Science (New York, N.Y.), Vol. 301, Issue 5633, pp. 643-6, 2003 (PubMed).
Freeman, Gangula, Welm et al.: "Conditional activation of fibroblast growth factor receptor (FGFR) 1, but not FGFR2, in prostate cancer cells leads to increased osteopontin induction, extracellular signal-regulated kinase activation, and in vivo proliferation." in: Cancer research, Vol. 63, Issue 19, pp. 6237-43, 2003 (PubMed).
|Hosts||Rabbit (57), Mouse (15), Goat (3), Rat (1)|
|Reactivities||Human (74), Mouse (Murine) (29), Rat (Rattus) (26), Cow (Bovine) (2), Cat (Feline) (1), Chicken (1), Dog (Canine) (1), Pig (Porcine) (1), Primate (1), Rabbit (1)|
|Applications||Western Blotting (WB) (54), ELISA (30), Immunofluorescence (IF) (24), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (20), Immunohistochemistry (IHC) (11), Flow Cytometry (FACS) (8), Immunoprecipitation (IP) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1)|
|Conjugates||APC (1), Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)|
|Epitopes||C-Term (5), N-Term (3), AA 362-374 (2), Extracellular Domain (2), Internal Region (2), AA 809-821 (1), N-Term,Arg22 (1)|