PIK3R1 antibody (N-Term)

Catalog No. ABIN392570

There is 1 publication for this product available. The Rabbit Polyclonal anti-PIK3R1 antibody is suitable to detect PIK3R1 in samples from Human and Rat. It has been validated for WB, IF, IHC (p) and FACS.

Quick Overview for PIK3R1 antibody (N-Term) (ABIN392570)

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PIK3R1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: RB11634

Product Details anti-PIK3R1 Antibody

Binding Specificity: AA 1-30, N-Term

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PI3KR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human PI3KR1.

Isotype: Ig Fraction

Application Details

Application Notes: IF: 1:25. WB: 1:2000. WB: 1:2000. IHC-P-Leica: 1:500. FC: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

References for anti-PIK3R1 antibody (ABIN392570)

Hu, Gu, Han, Zhang, Li, Tian, Young, Yuan: "Knockdown of AGR2 induces cellular senescence in prostate cancer cells." in: Carcinogenesis, Vol. 33, Issue 6, pp. 1178-86, (2012) (PubMed).

Target Details for PIK3R1

Target: PIK3R1 (PI3K p85a) (Phosphoinositide 3 Kinase, p85 alpha (PI3K p85a))

Alternative Name: PI3KR1

Background: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance.

Molecular Weight: 83598

Gene ID: 5295

NCBI Accession: NP_001229395, NP_852556, NP_852664, NP_852665

UniProt: P27986

Pathways: TCR Signaling, Response to Growth Hormone Stimulus, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Hepatitis C, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling, Warburg Effect