Unc-51 Like Kinase 2 (C. Elegans) (ULK2) (N-Term), (AA 235-264) antibody

Details for Product No. ABIN392692
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Antigen
Synonyms Unc51.2, AU015340, mKIAA0623, A830085I22Rik, ATG1B, ULK2
Epitope
N-Term, AA 235-264
(12), (10), (9), (8), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(53), (4), (1), (1), (1)
Host
Rabbit
(36), (20)
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
(3), (3), (3), (3), (3), (3)
Application
Western Blotting (WB), Immunohistochemistry (IHC)
(41), (33), (11), (9), (5), (4), (1)
Pubmed 1 reference available
Catalog no. ABIN392692
Quantity 400 µL
Price
291.50 $   Plus shipping costs $45.00
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  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 235-264 AA from the N-terminal region of human ULK2.
Clone RB12561
Isotype Ig
Specificity This ULK2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242~272 amino acids from the N-terminal region of human ULK2.
Predicted Reactivity Mouse (Murine)
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name ULK2
Background Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). Two human homologs of the yeast autophagy-specific kinase exist: ULK1(APG1) and ULK2. APG1 plays a critical role in regulating key elements of the autophagy pathway. APG1 stimulates autophagy, leading to autophagy-dependent restriction of cell growth and ultimately cell apoptosis at high levels of activity, and is a negative regulator of mTOR signaling.
Synonyms: Serine/threonine-protein kinase ULK2, unc-51-like kinase 2, KIAA0623
Molecular Weight 112726 DA
Gene ID 9706
UniProt Q8IYT8
Application Notes WB = 1:1000, IHC = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
anti-Unc-51 Like Kinase 2 (C. Elegans) (ULK2) (N-Term), (AA 235-264) antibody Western blot analysis of anti-ULK2 Antibody (N-term) (ABIN392692) in K562 cell line lysates (35 µg/lane). ULK2(arrow) was detected using the purified polyclonal antibody (1:60 dilution).
anti-Unc-51 Like Kinase 2 (C. Elegans) (ULK2) (N-Term), (AA 235-264) antibody (2) Formalin-fixed and paraffin-embedded human brain tissue reacted with ULK2 antibody (N-term) (ABIN392692), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining.
Background publications Yan, Kuroyanagi, Tomemori et al.: "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains." in: Oncogene, Vol. 18, Issue 43, pp. 5850-9, 1999 (PubMed).

Hosts (36), (20)
Reactivities (53), (4), (1), (1), (1)
Applications (41), (33), (11), (9), (5), (4), (1)
Conjugates (3), (3), (3), (3), (3), (3)
Epitopes (12), (10), (9), (8), (6), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Validation Images
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