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tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (AA 217-246), (C-Term) antibody

Details for Product No. ABIN392788, Supplier: Login to see
Antigen
  • hs1
  • gw128
  • kcip-1
  • 14-3-3beta
  • 1433b
  • YWHAB
  • DKFZp459L1720
  • GW128
  • HS1
  • KCIP-1
  • YWHAA
  • 1300003C17Rik
Alternatives
anti-Human tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide antibody for Immunoprecipitation
Epitope
AA 217-246, C-Term
18
11
11
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
106
36
34
6
4
4
3
2
2
2
2
1
1
Host
Rabbit
93
21
Clonality (Clone)
Polyclonal ()
Conjugate
Un-conjugated
6
5
5
2
2
1
1
Application
Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
94
48
36
25
23
10
9
6
4
1
1
Supplier
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Immunogen This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217-246 AA from the C-terminal region of human YWHAB.
Clone RB4064
Isotype Ig
Specificity This YWHAB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 217~246 amino acids from the C-terminal region of human YWHAB.
Predicted Reactivity Cow (Bovine),Chicken,Mouse (Murine),Monkey,Rat (Rattus),Zebrafish
Purification This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Alternative Name YWHAB (14-3-3 protein beta/alpha) (YWHAB Antibody Abstract)
Background YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.
Synonyms: 14-3-3 protein beta/alpha, Protein kinase C inhibitor protein-1, KCIP-1, Protein 1054
Molecular Weight 27951 DA
Gene ID 7529
UniProt P31946
Research Area Phospho-specific antibodies, Cell Signaling, Protein Modifications, Cell Cycle, Cell Structure
Pathways Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway
Application Notes IHC (p) = 1:50-100, WB = 1:1000, IF = 1:10-50
Restrictions For Research Use only
Format Liquid
Concentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Expiry Date 6 months
Supplier Images
Immunohistochemistry (IHC) image for anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (AA 217-246), (C-Term) antibody (ABIN392788) Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary ant...
Western Blotting (WB) image for anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (AA 217-246), (C-Term) antibody (ABIN392788) The anti-YWHAB Pab (ABIN392788) is used in Western blot to detect YWHAB in Jurkat cel...
Western Blotting (WB) image for anti-tyrosine 3-Monooxygenase/tryptophan 5-Monooxygenase Activation Protein, beta Polypeptide (YWHAB) (AA 217-246), (C-Term) antibody (ABIN392788) Western blot analysis of YWHAB (arrow) using rabbit polyclonal YWHAB Antibody (S232) ...
Background publications Komori, Ishizawa, Arai et al.: "Immunoexpression of 14-3-3 proteins in glial cytoplasmic inclusions of multiple system atrophy." in: Acta neuropathologica, Vol. 106, Issue 1, pp. 66-70, 2003 (PubMed).

Cavet, Lehoux, Berk: "14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity." in: The Journal of biological chemistry, Vol. 278, Issue 20, pp. 18376-83, 2003 (PubMed).

Li, Inoki, Vacratsis et al.: "The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3." in: The Journal of biological chemistry, Vol. 278, Issue 16, pp. 13663-71, 2003 (PubMed).

Parvaresch, Yesilkaya, Baer et al.: "14-3-3 binding to the IGF-1 receptor is mediated by serine autophosphorylation." in: FEBS letters, Vol. 532, Issue 3, pp. 357-62, 2002 (PubMed).

Shumway, Li, Xiong: "14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin." in: The Journal of biological chemistry, Vol. 278, Issue 4, pp. 2089-92, 2003 (PubMed).