TDP1 antibody (N-Term)

Catalog No. ABIN400858

This Mouse Monoclonal antibody specifically detects TDP1 in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for TDP1 antibody (N-Term) (ABIN400858)

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TDP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: AT1F2

Product Details anti-TDP1 Antibody

Binding Specificity: AA 1-298, N-Term

Specificity: The antibody recognizes human TDP1. Other species not tested.

Characteristics: Synonyms: Tyrosyl-DNA phosphodiesterase 1

Purification: Protein-G affinity chromatography

Immunogen: Recombinant human TDP1 (1-298 aa) purified from E. coli

Isotype: IgG2b

Application Details

Application Notes: ELISA. Western blot: 1/1,000-1/2,000. Immunohistochemistry on Paraffin Sections: 5 μg/mL
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for up to two weeks or (in aliquots) at -20 °C or -70 °Cfor longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for TDP1

Target: TDP1 (Tyrosyl-DNA Phosphodiesterase 1 (TDP1))

Alternative Name: TDP1

Background: Tyrosyl-DNA phosphodiesterase (TDP1) is a DNA repair enzyme that catalyzes the hydrolysis of a phophodiester bond between a tyrosine residue and a DNA 3' phosphate. This protein is a member of the phospholipase D (PLD) superfamily and contains two PLD phosphodiesterase domains. Mutations in TDP1 are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1) by interfering with DNA transcription or by inducting apoptosis in postmitotic neurons.Synonyms: Tyrosyl-DNA phosphodiesterase 1

Gene ID: 55775

UniProt: Q9NUW8