CCL3L1 antibody

Catalog No. ABIN401068

Product Details anti-CCL3L1 Antibody

Target: CCL3L1 (Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1))

Reactivity: Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCL3L1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody reacts to CCL3L1.

Purification: Affinity chromatography on Protein A

Immunogen: Recombinant protein raised in yeast, corresponding to the 70 amino acids of the mature swine CCL3L1 protein.

Isotype: IgG

Application Details

Application Notes: Western Blot: 1,0 μg/mL. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: Restore with 0.1 mL of deionized water (or equivalent).

Concentration: 1.0 mg/mL (by UV absorbance at 280 nm)

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2 containing 0.01 % (w/v) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Target Details for CCL3L1

Target: CCL3L1 (Chemokine (C-C Motif) Ligand 3-Like 1 (CCL3L1))

Alternative Name: LD78 beta / CCL3L1 (CCL3L1 Products)

Synonyms: 464.2 antibody, D17S1718 antibody, G0S19-2 antibody, LD78 antibody, LD78BETA antibody, MIP1AP antibody, SCYA3L antibody, SCYA3L1 antibody, C-C motif chemokine ligand 3 like 1 antibody, chemokine (C-C motif) ligand 3-like 1 antibody, CCL3L1 antibody

Background: Chemokine (C-C motif) ligand 3-like 1 (CCL3L1), also known as macrophage inflammatory protein 1 alpha (MIP-1 alpha, other synonyms: ld78beta, scya3l1, small inducible cytokine a3-like 1), is a member of the CC or beta chemokine subfamily that was originally purified from the conditioned media of an LPS-stimulated murine macrophage cell line. In humans, CCL3L1 is encoded by a variable copy-number gene. The CC family induces MCP1 and RANTES, and exhibits a variety of proinflammatory activities including chemotaxis, and functional and proliferative activation of leukocytes, lymphocytes, and macrophages. Its signal is transmitted through transmembrane receptors, CC chemokine receptors, CCR1, CCR3 and CCR5. CCL3L1/MIP-1 alpha acts as a chemoattractant to a variety of cells including monocytes, T cells, B cells and eosinophils. CCL3L1 binds to several chemokine receptors. In humans these receptors include chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. In swine, CCL3L1 protein is 86 % similar to CCL4 protein, and 73 % similar to CCL5.Synonyms: C-C motif chemokine 3-like 1, D17S1718, G0/G1 switch regulatory protein 19-2, G0S19-2, SCYA3L1, Small-inducible cytokine A3-like 1, Tonsillar lymphocyte LD78 beta protein

Gene ID: 414062

NCBI Accession: NP_001001437

UniProt: P16619

Pathways: Cellular Response to Molecule of Bacterial Origin