TREML1 antibody (C-Term)

Catalog No. ABIN401526

Product Details anti-TREML1 Antibody

Target: TREML1 (Triggering Receptor Expressed On Myeloid Cells-Like 1 (TREML1))

Binding Specificity: C-Term

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This TREML1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Sequence: CGPAQNPPNN QTPS

Specificity: This antibody detects TREML1 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Immunogen: Peptide from the C-Terminus of the protein sequence according to NP_835468.1. Genename: TREML1

Application Details

Application Notes: Peptide ELISA: Antibody detection limit dilution 1: 2000. Western blot: 0.3-1 μg/mL. Approx 30 kDa band observed in Human Bone Marrow lysates(calculated MW of 32.0 kDa according to NP_835468.1).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Tris saline, 0.02 % sodium azide, pH 7.3 with 0.5 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C.

Target Details for TREML1

Target: TREML1 (Triggering Receptor Expressed On Myeloid Cells-Like 1 (TREML1))

Alternative Name: TREML1 (TREML1 Products)

Synonyms: GLTL1825 antibody, PRO3438 antibody, TLT-1 antibody, TLT1 antibody, dJ238O23.3 antibody, 5430401J17Rik antibody, RGD1565175 antibody, triggering receptor expressed on myeloid cells 2 antibody, triggering receptor expressed on myeloid cells like 1 antibody, triggering receptor expressed on myeloid cells-like 1 antibody, LOC474898 antibody, TREML1 antibody, Treml1 antibody

Background: The TREMs (triggering receptors expressed on myeloid cells) represent a family of 5 receptors clustered on murine chromosome 17. TREM-like transcript-1 (TLT-1) was initially characterized as the putative inhibitory receptor within the TREM locus on chromosome 6 and was suggested to play a critical role in modulating TREM-associated immunity. It may also play a significant role in maintaining vascular hemostasis, coagulation, and inflammation at sites of injury through its location in platelets. TREML1 is the first ITIM-containing receptor carrying a potential Src homology 3 domain ligand. TREML1 transcripts are abundant in bone marrow cells, but not in lymphocytes, and phosphorylated TREML1 associates with SHP-1, suggesting that it is indeed an inhibitory receptor.Synonyms: TLT-1, TLT1, Trem-like transcript 1 protein, Triggering receptor expressed on myeloid cells-like protein 1

Gene ID: 340205

NCBI Accession: NP_835468

UniProt: Q86YW5