Recombination Signal Binding Protein For Immunoglobulin kappa J Region-Like (RBPJL) (Middle Region) antibody

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Antigen
Synonyms rbpsuhl, RBPSUHL, RBPJL, SUHL, RBP-L, Rbpsuhl
Epitope
Middle Region
(22), (16), (2), (2), (2), (1), (1)
Reactivity
Cow (Bovine), Dog (Canine), Fruit Fly (Drosophila melanogaster), Human, Mouse (Murine), Rat (Rattus), Zebrafish (Danio rerio)
(30), (2), (2), (1)
Host
Rabbit
(29), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (2), (2), (2)
Application
Western Blotting (WB)
(28), (16), (16), (15), (3), (1)
Pubmed 1 reference available
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Quantity 50 μg
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Immunogen Synthetic peptide directed towards the middle region of human RBPJL
Blocking Peptide Blocking peptide for this product available: Recombination Signal Binding Protein For Immunoglobulin kappa J Region-Like (RBPJL) (Middle Region) peptide (ABIN982776)
Sequence TIIGTESVEF SFSTSLACTL EPVTPVPLIS TLELSGGGDV ATLELHGENF
Predicted Reactivity Bovine : 100 %, Dog : 100 %, Guinea pig : 100 %, Horse : 100 %, Human : 100 %, Mouse : 100 %, Pig : 100 %, Rabbit : 100 %, Rat : 100 %, Chicken : 80 %
Characteristics This is a rabbit polyclonal antibody against RBPJL. It was validated on Western Blot using a cell lysate as a positive control.
Purification Affinity Purified
Alternative Name RBPJL (RBPJL Antibody Abstract)
Background RBPJL is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein. In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. However, unlike RBP-J, RBP-L does not interact with Notch receptors. RBP-L has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2 (EBNA2). RBPJL is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein.In mouse, recombining binding protein L (RBP-L) is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signalling pathway transcription factor RBP-J. However, unlike RBP-J, RBP-L does not interact with Notch receptors. RBP-L has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2 (EBNA2). The protein encoded by this gene is similar in sequence to the mouse RPB-L protein and Drosophila suppressor of hairless protein.
Molecular Weight 57 kDa
Gene ID 11317
NCBI Accession NM_014276, NP_055091
UniProt Q5QPV0
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 517 AA

Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 50 µL of distilled water.
Concentration 1 mg/mL
Buffer PBS buffer with 2 % sucrose
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For longer periods of storage, store at -20 °C
Supplier Images
Western Blotting (WB) image for anti-Recombination Signal Binding Protein For Immunoglobulin kappa J Region-Like (RBPJL) (Middle Region) antibody (ABIN404960) WB Suggested Anti-RBPJL Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Background publications Beres, Masui, Swift et al.: "PTF1 is an organ-specific and Notch-independent basic helix-loop-helix complex containing the mammalian Suppressor of Hairless (RBP-J) or its paralogue, RBP-L." in: Molecular and cellular biology, Vol. 26, Issue 1, pp. 117-30, 2005 (PubMed).

Catalog No. ABIN404960
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