AKAP1 antibody (C-Term)

Catalog No. ABIN405082

This Rabbit Polyclonal antibody specifically detects AKAP1 in WB. It exhibits reactivity toward Human.

Quick Overview for AKAP1 antibody (C-Term) (ABIN405082)

Target: AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AKAP1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-AKAP1 Antibody

Binding Specificity: C-Term

Sequence: VPFSNGVLKG ELSDLGAEDG WTMDAEADHS GVAAPPPGKR GTLITRCPGF

Predicted Reactivity: Human: 100%

Characteristics: This is a rabbit polyclonal antibody against AKAP1. It was validated on Western Blot using a cell lysate as a positive control.

Purification: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human AKAP1

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator.

Comment:

Antigen size: 593 AA

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles.

Storage: -20 °C

Storage Comment: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Target Details for AKAP1

Target: AKAP1 (A Kinase (PRKA) Anchor Protein 1 (AKAP1))

Alternative Name: AKAP1

Background: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. AKAP1 is a member of the AKAP family. It binds to type I and type II regulatory subunits of PKA and anchors them to the mitochondrion. This protein is speculated to be involved in the cAMP-dependent signal transduction pathway and in directing RNA to a specific cellular compartment.
Alias Symbols: AKAP, AKAP121, AKAP149, AKAP84, D-AKAP1, MGC1807, PRKA1, SAKAP84, PPP1R43
Protein Interaction Partner: MDM2, PRKACB, PRKACA, UBC, APP, TP73, USP7, PPP1CA, MYCBP, PTPN21, CAV1, PRKAR1A, PRKAR2B, PRKAR1B, PRKAR2A, AMY1C, SIAH2, MAATS1, AMY1A,
Protein Size: 593

Molecular Weight: 65 kDa

Gene ID: 8165

NCBI Accession: NM_139275, NP_644804

UniProt: Q92667

Pathways: Synaptic Membrane